{{Rsnum
|rsid=12720356
|Gene=TYK2
|Chromosome=19
|position=10359299
|Orientation=plus
|GMAF=0.04545
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=TYK2
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 1.8 | 21.2 | 77.0
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 7.0 | 93.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 3.0 | 97.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 5.2 | 94.8
| MKK | 0.0 | 0.0 | 0.0
| TSI | 1.0 | 12.7 | 86.3
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=21102463
|Trait=None
|Title=Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
|RiskAllele=G
|Pval=1E-12
|OR=1.1200
|ORtxt=[1.06-1.19]
|OA=1
}}
{{PMID Auto GWAS
|PMID=20953190
|Trait=None
|Title=A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1
|RiskAllele=A
|Pval=4E-11
|OR=1.4000
|ORtxt=[1.23-1.61]
|OA=1
}}

{{PMID Auto
|PMID=21140222
|Title=Meta-analysis of TYK2 gene polymorphisms association with susceptibility to autoimmune and inflammatory diseases
}}

{{PMID|15657875|OA=1
}} Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

{{PMID|18270328|OA=1
}} Somatic mutations and germline sequence variants in the expressed tyrosine kinase genes of patients with de novo acute myeloid leukemia.

{{PMID|19249008|OA=1
}} Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease.

{{PMID|19434718|OA=1
}} Variants in interferon-alpha pathway genes and response to pegylated interferon-Alpha2a plus ribavirin for treatment of chronic hepatitis C virus infection in the hepatitis C antiviral long-term treatment against cirrhosis trial.

{{PMID|19604093|OA=1
}} Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients.

{{PMID|19653082|OA=1
}} Strong evidence of a combination polymorphism of the tyrosine kinase 2 gene and the signal transducer and activator of transcription 3 gene as a DNA-based biomarker for susceptibility to Crohn's disease in the Japanese population.

{{GET Evidence
|gene=TYK2
|aa_change=Ile684Ser
|aa_change_short=I684S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12720356
|overall_frequency_n=737
|overall_frequency_d=10756
|overall_frequency=0.0685199
|n_genomes=4
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=0
|n_articles_annotated=0
|pph2_score=1.0
|nblosum100=5
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23000200
|Title=TYK2 rs34536443 polymorphism is associated with a decreased susceptibility to endometriosis-related infertility.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}