{{Rsnum
|rsid=12733102
|Gene=PADI4
|Chromosome=1
|position=17336210
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=C
|GMAF=0.01286
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=PADI4
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 0.0 | 1.6 | 98.4
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{Venter SNP
|rsid=12733102
|allele=C
|frequency=0.009
|uid=1103675033992
|type=homozygous_SNP
|hugo=PADI4
|ensembl gene=ENSG00000159339
|ensembl transcript=ENST00000290507
|sift=TOLERATED
|disease=PADI4 is thought to be a rheumatoid arthritis susceptibility locus (MIM:180300). Could have an important role in the pathogenesis of rheumatoid arthritis by increasing citrullination of proteins in rheumatoid arthritis synovial tissues, leading, in a cytokine-rich milieu, to a break in tolerance to citrullinated peptides processed and presented in the appropriate HLA context.
}}

{{ neighbor
| rsid = 1748033
| distance = 43
}}
{{ neighbor
| rsid = 1621005
| distance = 46
}}

{{GET Evidence
|gene=PADI4
|aa_change=Arg131Thr
|aa_change_short=R131T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12733102
|overall_frequency_n=178
|overall_frequency_d=10758
|overall_frequency=0.0165458
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.065
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}