{{Rsnum
|rsid=12753193
|Chromosome=1
|position=65703996
|Orientation=plus
|GMAF=0.4541
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 46.9 | 41.6 | 11.5
| HCB | 0.0 | 18.7 | 81.3
| JPT | 0.9 | 20.4 | 78.8
| YRI | 24.8 | 48.3 | 26.9
| ASW | 22.8 | 50.9 | 26.3
| CHB | 0.0 | 18.7 | 81.3
| CHD | 0.9 | 25.7 | 73.4
| GIH | 29.7 | 49.5 | 20.8
| LWK | 36.7 | 50.5 | 12.8
| MEX | 28.6 | 39.3 | 32.1
| MKK | 40.4 | 44.2 | 15.4
| TSI | 38.6 | 48.5 | 12.9
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=19060910
|Trait=Other metabolic traits
|Title=Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
|RiskAllele=G
|Pval=4E-7
|OR=0.13
|ORtxt=[-0.02-0.27] mmol/l decrease
|OA=1
}}

{{PharmGKB
|RSID=rs12753193
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060910; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. (Initial Sample Size: 4,763 individuals; Replication Sample Size: NR); (Region: 1p31.3; Reported Gene(s): LEPR; Risk Allele: rs12753193-G); (p-value= 0.0000004).This variant is associated with Other metabolic traits.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740288
}}

{{PMID Auto
|PMID=20585554
|Title=On the use of variance per genotype as a tool to identify quantitative trait interaction effects: a report from the Women's Genome Health Study
|OA=1
}}

{{PMID Auto
|PMID=18439548
|Title=Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=18439552
|Title=Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12753193
|overall_frequency_n=71
|overall_frequency_d=128
|overall_frequency=0.554688
|n_genomes=39
|n_genomes_annotated=0
|n_haplomes=54
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}