{{Rsnum
|rsid=12770228
|Gene=C10orf114
|Chromosome=10
|position=21783634
|Orientation=plus
|GMAF=0.1708
|Assembly=GRCh37.p10
|GenomeBuild=37.5
|dbSNPBuild=138
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CASC10
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 10.6 | 39.8 | 49.6
| HCB | 0.0 | 2.2 | 97.8
| JPT | 0.0 | 0.9 | 99.1
| YRI | 1.4 | 8.8 | 89.8
| ASW | 3.5 | 17.5 | 78.9
| CHB | 0.0 | 2.2 | 97.8
| CHD | 0.0 | 0.9 | 99.1
| GIH | 8.9 | 33.7 | 57.4
| LWK | 0.0 | 8.2 | 91.8
| MEX | 3.4 | 27.6 | 69.0
| MKK | 0.6 | 11.5 | 87.8
| TSI | 14.7 | 44.1 | 41.2
| HapMapRevision=28
}}[[rs12770228]] is a SNP in a region on ch 10p12.31 designated as the chromosome 10 open reading frame 114 [[C10orf114]]; it is just upstream of the [[MLLT10]] gene.

A study of ~1,600 patients with [[meningioma]], all of European ancestry, concluded that increased risk for the disease was associated with [[rs12770228]](A) alleles. The odds ratio was 1.37 (CI: 1.18-1.59, p = 4 x 10e-4). A nearby SNP, [[rs11012732]], was also linked to [[meningioma]] risk.{{PMID|21804547}}

{{PMID Auto
|PMID=24755950
|Title=Brain tumor risk according to germ-line variation in the MLLT10 locus
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}