{{Rsnum
|rsid=12777823
|Gene=LOC100130970
|Chromosome=10
|position=96405502
|Orientation=plus
|GMAF=0.2213
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 1.8 | 24.8 | 73.5
| HCB | 8.0 | 48.9 | 43.1
| JPT | 9.7 | 44.2 | 46.0
| YRI | 7.5 | 40.8 | 51.7
| ASW | 1.8 | 31.6 | 66.7
| CHB | 8.0 | 48.9 | 43.1
| CHD | 11.0 | 34.9 | 54.1
| GIH | 14.9 | 32.7 | 52.5
| LWK | 7.3 | 40.0 | 52.7
| MEX | 1.7 | 24.1 | 74.1
| MKK | 5.1 | 35.3 | 59.6
| TSI | 1.0 | 18.6 | 80.4
| HapMapRevision=28
}}[http://jama.ama-assn.org/cgi/content/short/302/8/849 JAMA] [[rs12777823]] and [[rs4244285]] implicated in platelet response to [[clopidogrel]]
{{PMID Auto
|PMID=19706858
|Title=Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
|OA=1
}}

{{PharmGKB
|RSID=rs12777823
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19706858
|Annotation=A GWAS found this variant (rs12777823) was the most significantly associated SNP with clopidogrel response. This SNP was in strong linkage disequilibrium with 12 further SNPs within the CYP2C18-CYP2C19-CYP2C9-CYP2C8 cluster (rs12777823; rs10109204; rs2025445; rs1326837; rs717238; rs2860838; rs2860903; rs9332105; rs9332113; rs12572351; rs10509679; rs1934951; rs1934680) and also with the loss-of-function variant CYP2C19*2 (rs4244285). Further findings in this study showed that the CYP2C19*2 genotype accounted for most of all the initially found association with diminished platelet response to clopidogrel.
|Drugs=clopidogrel
|Drug Classes=
|Diseases=Cardiovascular Diseases
|Curation Level=Curated
|PharmGKB Accession ID=PA165106754
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12777823
|overall_frequency_n=26
|overall_frequency_d=128
|overall_frequency=0.203125
|n_genomes=19
|n_genomes_annotated=0
|n_haplomes=21
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23755828
|Title=Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}