{{Rsnum
|rsid=12779790
|Chromosome=10
|position=12328010
|Orientation=plus
|GMAF=0.1731
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}
{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 63.5 | 28.6 | 7.9
| HCB | 73.3 | 26.7 | 0.0
| JPT | 78.0 | 19.5 | 2.4
| YRI | 90.3 | 9.7 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 73.3 | 26.7 | 0.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

{{GWAS Summary
|SNP=rs12779790
|PubMedID=18372903
|Condition=Type 2 diabetes
|Gene=CDC123,CAMK1D
|Risk Allele=G
|pValue=1.00E-010
|OR=1.11
|95CI=1.07-1.14
|OA=1
}}
{{PMID Auto
|PMID=19455301
|Title=Replication study for the association of new meta-analysis-derived risk loci with susceptibility to type 2 diabetes in 6,244 Japanese individuals
}}

{{PMID Auto
|PMID=19789630
|Title=Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients--EUGENE2 study
|OA=1
}}

{{PharmGKB
|RSID=rs12779790
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18372903; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes (Initial Sample Size: 4,549 cases, 5,579 controls; Replication Sample Size: 24,194 cases, 55,598 controls; Risk Allele: rs12779790-G).
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356764
}}

{{PMID|18567820|OA=1
}} Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged Danes.

{{PMID|18591388|OA=1
}} Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.

{{PMID|18694974|OA=1
}} Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.

{{PMID|18714373|OA=1
}} Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes.

{{PMID|18782870|OA=1
}} Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.

{{PMID|18852197|OA=1
}} Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.

{{PMID|19020323|OA=1
}} Genotype score in addition to common risk factors for prediction of type 2 diabetes.

{{PMID|19056611|OA=1
}} Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.

{{PMID|19096518|OA=1
}} Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.

{{PMID|19207020|OA=1
}} Meta-analysis in genome-wide association studies.

{{PMID|19247373}} Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs.

{{PMID|19324937|OA=1
}} Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.

{{PMID|19341491|OA=1
}} Genome-based prediction of common diseases: methodological considerations for future research.

{{PMID|19401414|OA=1
}} Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.

{{PMID|19460916|OA=1
}} Genetic architecture of type 2 diabetes: recent progress and clinical implications.

{{PMID|19502414|OA=1
}} Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.

{{PMID|19526209|OA=1
}} Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

{{PMID|19602701|OA=1
}} Underlying genetic models of inheritance in established type 2 diabetes associations.

{{PMID|19639606|OA=1
}} Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.

{{PMID|19741467}} Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.

{{PMID|19862325|OA=1
}} PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.

{{PMID|19956539|OA=1
}} How many genetic variants remain to be discovered?

{{PMID|20017978|OA=1
}} Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.

{{PMID|20018041|OA=1
}} The effect of multiple genetic variants in predicting the risk of type 2 diabetes.

{{PMID|20043853|OA=1
}} Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.

{{PMID|20075150|OA=1
}} Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.

{{PMID|20144327|OA=1
}} A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.

{{PMID|20161779|OA=1
}} Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.

{{PMID|20712903|OA=1
}} Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.

{{PMID|21278902|OA=1
}} Genetic risk profiling for prediction of type 2 diabetes.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12779790
|overall_frequency_n=15
|overall_frequency_d=128
|overall_frequency=0.117188
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=12
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=22923468
|Title=Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.
|OA=1
}}

{{PMID Auto
|PMID=23298195
|Title=Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.
}}

{{PMID Auto
|PMID=23334806
|Title=Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=23462794
|Title=Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
|OA=1
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}