{{Rsnum
|rsid=12807809
|Chromosome=11
|position=124736389
|Orientation=plus
|GMAF=0.213
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 4.4 | 26.5 | 69.0
| HCB | 8.8 | 31.4 | 59.9
| JPT | 8.8 | 35.4 | 55.8
| YRI | 6.8 | 47.6 | 45.6
| ASW | 8.8 | 24.6 | 66.7
| CHB | 8.8 | 31.4 | 59.9
| CHD | 12.8 | 33.0 | 54.1
| GIH | 2.0 | 19.8 | 78.2
| LWK | 8.2 | 40.9 | 50.9
| MEX | 3.4 | 29.3 | 67.2
| MKK | 4.5 | 41.9 | 53.5
| TSI | 0.0 | 24.5 | 75.5
| HapMapRevision=28
}}[http://blog.23andme.com/2009/07/03/snpwatch-researchers-show-importance-of-common-dna-variants-in-schizophrenia/ 23andMe blog] [[schizophrenia]]
*[[rs3131296]](C) increased the odds of schizophrenia by 1.19x
*[[rs12807809]](T) increased the odds of schizophrenia by 1.15x
*[[rs9960767]](C) increased the odds of schizophrenia by 1.23 times.

{{PMID|20673877}} Although several of the SNPs reported in {{PMID|19571808|OA=1
}} to be associated with increased risk for [[schizophrenia]] were replicated in this study of Han Chinese, [[rs12807809]] did not (i.e. it was not found to be associated with increased risk in this study of ~2,500 Chinese patients).

{{PMID Auto GWAS
|PMID=19571808
|Trait=Schizophrenia
|Title=Common variants conferring risk of schizophrenia
|RiskAllele=T
|Pval=2E-9
|OR=1.15
|ORtxt=[NR]
|OA=1
}}

{{omim
|id=181500
|rsnum=12807809
}}

{{PMID Auto
|PMID=21538840
|Title=Analysis of neurogranin (NRGN) in schizophrenia
}}

{{PMID Auto
|PMID=22461181
|Title=Functional genetic variation at the NRGN gene and schizophrenia: Evidence from a gene-based case-control study and gene expression analysis
}}

{{PMID Auto
|PMID=22253779
|Title=Impact of the Genome Wide Supported NRGN Gene on Anterior Cingulate Morphology in Schizophrenia
|OA=1
}}

{{PMID|20485477|OA=1
}} New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?

{{PMID|21112188}} A neuropsychological investigation of the genome wide associated schizophrenia risk variant NRGN rs12807809.

{{PMID|22306195}} Genetic and functional analysis of the gene encoding neurogranin in schizophrenia.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12807809
|overall_frequency_n=29
|overall_frequency_d=128
|overall_frequency=0.226562
|n_genomes=19
|n_genomes_annotated=0
|n_haplomes=27
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=24386483
|Title=Effects of the Neurogranin Variant rs12807809 on Thalamocortical Morphology in Schizophrenia
|OA=1
}}

{{PMID Auto
|PMID=21799211
|Title=The effect of neurogranin on neural correlates of episodic memory encoding and retrieval.
|OA=1
}}

{{PMID Auto
|PMID=22005930
|Title=Genome-wide association study of Alzheimer's disease with psychotic symptoms.
|OA=1
}}

{{PMID Auto
|PMID=24098564
|Title=The impact of genome-wide supported schizophrenia risk variants in the neurogranin gene on brain structure and function
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}