{{Rsnum
|rsid=12821256
|Gene=KITLG
|Chromosome=12
|position=88934558
|Orientation=plus
|GMAF=0.05372
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.9 | 27.4 | 71.7
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 1.8 | 98.2
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 4.0 | 96.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 3.4 | 96.6
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 7.8 | 92.2
| HapMapRevision=28
}}A 2007 study based on the Icelanders and Dutch concluded that individuals with an [[rs12821256]](C) allele were ~2x fold more likely to have blond than brown [[hair color]]. The specific odds ratio claimed is 2.32, p = 5.5 x 10<sup>-14</sup>.{{PMID|17952075}}

{{GWAS Summary
|SNP=rs12821256
|PubMedID=17952075
|Condition=Blond vs. brown hair
|Gene=KITLG
|Risk Allele=C
|pValue=2.00E-014
|OR=2.32
|95CI=1.86-2.92
}}

{{omim
|desc=SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 7; SHEP7
|id=611664
|rsnum=12821256
}}

{{omim
|id=184745
|desc=KIT LIGAND; KITLG
|rsnum=12821256
}}

{{PharmGKB
|RSID=rs12821256
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17952075; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genetic determinants of hair, eye and skin pigmentation in Europeans (Initial Sample Size: 2,986 individuals; Replication Sample Size: 3,932 individuals). This variant is associated with blond vs. brown hair.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356692
}}

{{omim
|id=184745
|rsnum=12821256
|variant=0001
}}

{{PMID Auto
|PMID=18483556
|Title=A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
|OA=1
}}

{{PMID Auto
|PMID=20042077
|Title=Genetic determinants of hair and eye colours in the Scottish and Danish populations.
|OA=1
}}

{{PMID Auto
|PMID=20585627
|Title=Web-based, participant-driven studies yield novel genetic associations for common traits.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12821256
|overall_frequency_n=7
|overall_frequency_d=128
|overall_frequency=0.0546875
|n_genomes=4
|n_genomes_annotated=0
|n_haplomes=4
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23548203
  |Trait=Hair color
  |Title=Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
  |RiskAllele=C
  |Pval=7E-19
  |OR=.18
  |ORtxt=[0.14-0.22] unit increase
  }}

{{ClinVar
|ALT=C
|CAF=0.9463; 0.05372
|CHROM=12
|CLNACC=RCV000013659.23
|CLNALLE=1
|CLNDBN=Skin/hair/eye pigmentation, variation in, 7
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C2674081:611664
|CLNHGVS=NC_000012.11:g.89328335T>C
|CLNSIG=5
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=184745.0001
|COMMON=1
|Disease=Skin/hair/eye pigmentation
|FwdALT=C
|FwdREF=T
|REF=T
|RSPOS=89328335
|Reversed=0
|SAO=0
|SSR=0
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|VC=SNV
|VP=0x05016800000015051f130100
|WGT=0
|dbSNPBuildID=121
|rsid=12821256
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}