{{Rsnum
|rsid=12828016
|Gene=WNK1
|Chromosome=12
|position=889199
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=T
|GMAF=0.3861
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=WNK1
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 34.5 | 46.9 | 18.6
| HCB | 52.6 | 38.7 | 8.8
| JPT | 42.5 | 45.1 | 12.4
| YRI | 20.4 | 49.0 | 30.6
| ASW | 17.5 | 56.1 | 26.3
| CHB | 52.6 | 38.7 | 8.8
| CHD | 53.2 | 33.9 | 12.8
| GIH | 22.8 | 49.5 | 27.7
| LWK | 25.7 | 47.7 | 26.6
| MEX | 40.4 | 49.1 | 10.5
| MKK | 28.8 | 51.9 | 19.2
| TSI | 33.3 | 48.0 | 18.6
| HapMapRevision=28
}}{{Venter SNP
|rsid=12828016
|allele=T
|frequency=0.392
|uid=1103649345724
|type=heterozygous_SNP
|hugo=WNK1
|ensembl gene=ENSG00000060237
|ensembl transcript=ENST00000315939
|sift=
|disease=Defects in WNK1 are a cause of pseudohypoaldosteronism type II (PHAII) (MIM:145260). PHAII is an autosomal dominant disease characterized by severe hypertension, hyperkalemia, and sensitivity to thiazide diuretics which may result from a chloride shunt in the renal distal nephron.
}}

{{PMID Auto
|PMID=23059770
|Title=Common Variation in With No-Lysine Kinase 1 (WNK1) and Blood Pressure Responses to Dietary Sodium or Potassium Interventions
}}

{{GET Evidence
|gene=WNK1
|aa_change=Met2068Ile
|aa_change_short=M2068I
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12828016
|n_genomes=1
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_testable=Y
|nblosum100=-1
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}