{{Rsnum
|rsid=12896399
|Chromosome=14
|position=92307319
|Orientation=plus
|GMAF=0.2893
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 16.8 | 52.2 | 31.0
| HCB | 55.5 | 32.8 | 11.7
| JPT | 24.8 | 55.8 | 19.5
| YRI | 99.3 | 0.7 | 0.0
| ASW | 86.0 | 14.0 | 0.0
| CHB | 55.5 | 32.8 | 11.7
| CHD | 54.1 | 33.9 | 11.9
| GIH | 47.5 | 41.6 | 10.9
| LWK | 96.4 | 3.6 | 0.0
| MEX | 56.9 | 39.7 | 3.4
| MKK | 75.0 | 24.4 | 0.6
| TSI | 39.2 | 43.1 | 17.6
| HapMapRevision=28
}}

{{doi|10.1371/journal.pgen.1000074}} associated with [[hair color]] [[rs12896399]] [[rs12203592]]

{{doi|10.1371/journal.pgen.1000993}}

{{PMID Auto GWAS
|PMID=18483556
|Trait=Black vs. blond hair color
|Title=A Genome-Wide Association Study Identifies Novel Alleles Associated with Hair Color and Skin Pigmentation
|RiskAllele=G
|Pval=7.9999999999999993E-21
|OR=0.18
|ORtxt=[0.14-0.22] increase in hair color score
|OA=1
}}
{{PMID Auto GWAS
|PMID=17952075
|Trait=Blond vs. brown hair
|Title=Genetic determinants of hair, eye and skin pigmentation in Europeans
|RiskAllele=T
|Pval=9.9999999999999997E-49
|OR=2.56
|ORtxt=[2.12-3.09]
}}

{{omim
|desc=SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 6; SHEP6
|id=210750
|rsnum=12896399
}}

{{omim
|id=609840
|desc=SOLUTE CARRIER FAMILY 24 (SODIUM/POTASSIUM/CALCIUM EXCHANGER), MEMBER
|rsnum=12896399
}}

{{PMID Auto GWAS
|PMID=20585627
|Trait=Eye color
|Title=Web-based, participant-driven studies yield novel genetic associations for common traits
|RiskAllele=G
|Pval=2E-23
|OR=1.73
|ORtxt=[NR]
|OA=1
}}

{{omim
|id=609840
|rsnum=12896399
|variant=0001
}}

{{PMID Auto
|PMID=19609347
|Title=A genome-wide association study of hypertension and blood pressure in African Americans.
|OA=1
}}

{{PMID Auto
|PMID=19884608
|Title=Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations.
|OA=1
}}

{{PMID Auto
|PMID=20463881
|Title=Digital quantification of human eye color highlights genetic association of three new loci.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12896399
|overall_frequency_n=36
|overall_frequency_d=128
|overall_frequency=0.28125
|n_genomes=23
|n_genomes_annotated=0
|n_haplomes=29
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23548203
  |Trait=Eye color
  |Title=Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
  |RiskAllele=G
  |Pval=3E-7
  |OR=.27
  |ORtxt=[0.17-0.37] unit decrease
  }}

{{PMID Auto
|PMID=23771755
|Title=Improved eye- and skin-color prediction based on 8 SNPs.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}