{{Rsnum
|rsid=12916
|Gene=HMGCR
|Chromosome=5
|position=75360714
|Orientation=plus
|GMAF=0.4096
|Gene_s=HMGCR
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 16.8 | 46.9 | 36.3
| HCB | 27.6 | 51.5 | 20.9
| JPT | 25.0 | 58.0 | 17.0
| YRI | 4.8 | 27.2 | 68.0
| ASW | 8.8 | 28.1 | 63.2
| CHB | 27.6 | 51.5 | 20.9
| CHD | 32.4 | 46.3 | 21.3
| GIH | 34.7 | 53.5 | 11.9
| LWK | 5.5 | 48.2 | 46.4
| MEX | 14.0 | 33.3 | 52.6
| MKK | 5.8 | 37.2 | 57.1
| TSI | 17.6 | 46.1 | 36.3
| HapMapRevision=28
}}{{PMID Auto
|PMID=20235787
|Title=Common sequence variants in pharmacodynamic and pharmacokinetic pathway-related genes conferring LDL cholesterol response to statins
}}

{{PMID Auto GWAS
|PMID=20864672
|Trait=None
|Title=Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease
|RiskAllele=T
|Pval=1E-11
|OR=0.02
|ORtxt=[0.01-0.03] unit decrease
|OA=1
}}

{{omim
|id=142910
|rsnum=12916
}}

{{PMID Auto GWAS
|PMID=20686565
|Trait=None
|Title=Biological, clinical and population relevance of 95 loci for blood lipids.
|RiskAllele=C
|Pval=5.6E-45
|OR=2.4500
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=19682379
|Title=TagSNP transferability and relative loss of variability prediction from HapMap to an admixed population.
|OA=1
}}

{{PMID Auto
|PMID=19913121
|Title=Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
|OA=1
}}

{{PMID Auto
|PMID=20578904
|Title=Common variants of HMGCR, CETP, APOAI, ABCB1, CYP3A4, and CYP7A1 genes as predictors of lipid-lowering response to atorvastatin therapy.
}}

http://www.medscape.com/viewarticle/832327
Each additional allele of rs17238484(G) was associated with a mean 0.06-mmol/L lower LDL-cholesterol level. Similar reductions were associated with [[rs12916]] SNP. In addition, they found that each additional allele of rs17238484-G was associated with a higher body weight (0.30 kg), waist circumference (0.32 cm), and plasma insulin concentration (1.62%) and plasma glucose concentration (0.23%). Again, the [[rs12916]] SNP had similar effect

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}