{{Rsnum
|rsid=12917
|Gene=MGMT
|Chromosome=10
|position=131506283
|Orientation=plus
|GMAF=0.1506
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=132
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 80.0 | 19.1 | 0.9
| HCB | 81.5 | 17.8 | 0.7
| JPT | 66.7 | 31.5 | 1.8
| YRI | 64.4 | 33.6 | 2.1
| ASW | 66.7 | 33.3 | 0.0
| CHB | 81.5 | 17.8 | 0.7
| CHD | 78.5 | 21.5 | 0.0
| GIH | 80.2 | 18.8 | 1.0
| LWK | 67.6 | 28.7 | 3.7
| MEX | 52.6 | 42.1 | 5.3
| MKK | 58.1 | 35.8 | 6.1
| TSI | 70.3 | 26.7 | 3.0
| HapMapRevision=28
}}{{PMID Auto
|PMID=21075068
|Title=SMAD7 and MGMT genotype variants and cancer incidence in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk Study
}}

{{PMID Auto
|PMID=20938339
|Title=Temozolomide-induced severe myelosuppression: analysis of clinically associated polymorphisms in two patients
}}

{{PMID Auto
|PMID=16385451
|Title=A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
|OA=1
}}

{{PMID Auto
|PMID=16857995
|Title=Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.
|OA=1
}}

{{PMID Auto
|PMID=17119116
|Title=Gene-nutrient interactions among determinants of folate and one-carbon metabolism on the risk of non-Hodgkin lymphoma: NCI-SEER case-control study.
|OA=1
}}

{{PMID Auto
|PMID=17267408
|Title=Allelic imbalance in gene expression as a guide to cis-acting regulatory single nucleotide polymorphisms in cancer cells.
|OA=1
}}

{{PMID Auto
|PMID=17482892
|Title=Human variants of O6-alkylguanine-DNA alkyltransferase.
|OA=1
}}

{{PMID Auto
|PMID=18191955
|Title=Correlating observed odds ratios from lung cancer case-control studies to SNP functional scores predicted by bioinformatic tools.
|OA=1
}}

{{PMID Auto
|PMID=18547414
|Title=Genotyping panel for assessing response to cancer chemotherapy.
|OA=1
}}

{{PMID Auto
|PMID=18708406
|Title=Variants of DNA repair genes and the risk of biliary tract cancers and stones: a population-based study in China.
|OA=1
}}

{{PMID Auto
|PMID=18990748
|Title=International Lung Cancer Consortium: pooled analysis of sequence variants in DNA repair and cell cycle pathways.
|OA=1
}}

{{PMID Auto
|PMID=19124499
|Title=Association and interactions between DNA repair gene polymorphisms and adult glioma.
|OA=1
}}

{{PMID Auto
|PMID=19318434
|Title=Associations between polymorphisms in DNA repair genes and glioblastoma.
|OA=1
}}

{{PMID Auto
|PMID=19438866
|Title=Polymorphisms in genes involved in DNA repair, cell growth, oxidative stress and inflammatory response, and melanoma risk.
|OA=1
}}

{{PMID Auto
|PMID=19536092
|Title=Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array.
|OA=1
}}

{{PMID Auto
|PMID=21926110
|Title=Population-specific genetic associations with oesophageal squamous cell carcinoma in South Africa.
|OA=1
}}

{{PMID Auto
|PMID=22430443
|Title=Occupational solvent exposure, genetic variation of DNA repair genes, and the risk of non-Hodgkin's lymphoma.
|OA=1
}}

{{GET Evidence
|gene=MGMT
|aa_change=Leu84Phe
|aa_change_short=L84F
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12917
|overall_frequency_n=25
|overall_frequency_d=128
|overall_frequency=0.195312
|n_genomes=20
|n_genomes_annotated=0
|n_haplomes=21
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.001
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24084248
|Title=The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes
}}

{{PMID Auto
|PMID=24500421
|Title=Association between DNA repair gene polymorphisms and risk of glioma: A systematic review and meta-analysis
}}

{{PMID Auto
|PMID=24552298
|Title=Association Between Six Genetic Polymorphisms and Colorectal Cancer: A Meta-Analysis
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}