{{Rsnum
|rsid=12918952
|Gene=WWOX
|Chromosome=16
|position=78386878
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.3269
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Status=Merged
|Merged=11545029
|Gene_s=WWOX
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 36.3 | 46.0 | 17.7
| HCB | 0.0 | 14.0 | 86.0
| JPT | 0.9 | 17.1 | 82.0
| YRI | 0.7 | 12.2 | 87.1
| ASW | 1.8 | 39.3 | 58.9
| CHB | 0.0 | 14.0 | 86.0
| CHD | 0.0 | 11.9 | 88.1
| GIH | 6.9 | 42.6 | 50.5
| LWK | 3.7 | 19.3 | 77.1
| MEX | 16.1 | 46.4 | 37.5
| MKK | 0.0 | 23.7 | 76.3
| TSI | 36.6 | 45.5 | 17.8
| HapMapRevision=28
}}

{{Venter SNP
|rsid=12918952
|allele=A
|frequency=0.621
|uid=1103645522665
|type=homozygous_SNP
|hugo=Q9NZC7-8
|ensembl gene=ENSG00000186153
|ensembl transcript=ENST00000329729
|sift=TOLERATED
|disease=Defects in WWOX may be involved in esophageal squamous cell carcinoma (ESCC) (MIM:133239).
}}

{{PMID Auto
|PMID=18674750
|Title=WW-domain-containing oxidoreductase is associated with low plasma HDL-C levels.
|OA=1
}}

{{PMID Auto
|PMID=19844255
|Title=Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects.
|OA=1
}}

{{PMID Auto
|PMID=22693020
|Title=The polymorphisms and haplotypes of WWOX gene are associated with the risk of lung cancer in southern and eastern Chinese populations.
}}

{{GET Evidence
|gene=WWOX
|aa_change=Ala179Thr
|aa_change_short=A179T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs12918952
|overall_frequency_n=4526
|overall_frequency_d=9872
|overall_frequency=0.458468
|n_genomes=23
|n_genomes_annotated=0
|n_haplomes=29
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.002
|nblosum100=1
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}