{{Rsnum
|rsid=12953717
|Gene=SMAD7
|Chromosome=18
|position=48927559
|Orientation=plus
|GMAF=0.3251
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SMAD7
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 39.8 | 45.1 | 15.0
| HCB | 58.4 | 35.8 | 5.8
| JPT | 70.8 | 25.7 | 3.5
| YRI | 57.1 | 34.7 | 8.2
| ASW | 59.6 | 33.3 | 7.0
| CHB | 58.4 | 35.8 | 5.8
| CHD | 49.5 | 39.4 | 11.0
| GIH | 46.5 | 44.6 | 8.9
| LWK | 72.7 | 26.4 | 0.9
| MEX | 43.1 | 46.6 | 10.3
| MKK | 64.7 | 29.5 | 5.8
| TSI | 21.6 | 47.1 | 31.4
| HapMapRevision=28
}}[[rs12953717]] is one of 3 SNPs in the [[SMAD7]] gene associated with risk for [[colorectal cancer]], based on a large study (7,400+ cases) conducted in the UK. The odds ratios show an increased risk for the minor [[rs12953717]](T) allele; the OR for (T;T) homozygotes is 1.37 (CI: 1.25-1.5), and for (C;T) heterozygotes 1.11 (CI: 1.03-1.2), overall p=9x10<sup>-12</sup>.{{PMID|17934461}}

{{ neighbor
| rsid = 4939827
| distance = 466
}}

{{PMID Auto
|PMID=19562778
|Title=Wnt antagonist gene polymorphisms and renal cancer
|OA=1
}}
{{PMID Auto
|PMID=19843678
|Title=Enrichment of Low Penetrance Susceptibility Loci in a Dutch Familial Colorectal Cancer Cohort
}}

{{PMID Auto
|PMID=20124488
|Title=Increased Risk of Colon Cancer Associated with a Genetic Polymorphism of SMAD7
|OA=1
}}

{{PMID Auto
|PMID=21179028
|Title=Replication study of SNP associations for colorectal cancer in Hong Kong Chinese
|OA=1
}}
{{PMID Auto
|PMID=21221812
|Title=A risk-associated single nucleotide polymorphism of SMAD7 is common to colorectal, gastric, and lung cancers in a Han Chinese population
}}

{{PMID Auto
|PMID=18231913
|Title=Lack of a relationship between the common 18q24 variant rs12953717 and risk of chronic lymphocytic leukemia.
}}

{{PMID Auto
|PMID=18372901
|Title=Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
|OA=1
}}

{{PMID Auto
|PMID=19011631
|Title=Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|OA=1
}}

{{PMID Auto
|PMID=19155440
|Title=Meta association of colorectal cancer confirms risk alleles at 8q24 and 18q21.
|OA=1
}}

{{PMID Auto
|PMID=19357349
|Title=Association of common genetic variants in SMAD7 and risk of colon cancer.
|OA=1
}}

{{PMID Auto
|PMID=19395656
|Title=The colorectal cancer risk at 18q21 is caused by a novel variant altering SMAD7 expression.
|OA=1
}}

{{PMID Auto
|PMID=23472153
|Title=Association of SMAD7 rs12953717 Polymorphism with Cancer: A Meta-Analysis
|OA=1
}}

{{PMID Auto
|PMID=23560096
|Title=Genetic Variations in SMAD7 Are Associated with Colorectal Cancer Risk in the Colon Cancer Family Registry
|OA=1
}}

{{PMID Auto
|PMID=24448986
|Title=Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians
}}

{{PMID Auto
|PMID=22848671
|Title=Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}