{{Rsnum
|rsid=13207033
|Chromosome=6
|position=137644281
|Orientation=plus
|GMAF=0.1905
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=(A;A) appears protective against rheumatoid arthritis
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 8.0 | 31.2 | 60.7
| HCB | 0.7 | 17.5 | 81.8
| JPT | 0.9 | 16.8 | 82.3
| YRI | 1.4 | 17.7 | 81.0
| ASW | 3.5 | 28.1 | 68.4
| CHB | 0.7 | 17.5 | 81.8
| CHD | 0.0 | 19.3 | 80.7
| GIH | 15.8 | 43.6 | 40.6
| LWK | 0.0 | 13.6 | 86.4
| MEX | 6.9 | 48.3 | 44.8
| MKK | 1.9 | 26.3 | 71.8
| TSI | 7.8 | 45.1 | 47.1
| HapMapRevision=28
}}[[rs13207033]] can be considered a proxy for [[rs10499194]], since it is perfectly correlated to it (r<sup>2</sup> =1). In WTCCC data, the minor allele of [[rs13207033]] was seen to be less frequent in patients with [[rheumatoid arthritis]] than in controls, just as [[rs10499194]] has been seen in other studies.{{PMID|17982456|OA=1
}}

{{PMID|19417005|OA=1
}} [[rheumatoid arthritis]]
*[[rs6920220]] [P= 2.6 x 10(-6), OR 1.22 (1.13-1.33)]. 
*[[rs5029937]]
*[[rs13207033]] protective [P= 0.0001, OR 0.86 (0.8-0.93)] perfectly correlated with [[rs10499194]]
The combination of the carriage of both risk alleles of rs6920220 and rs5029937 together with the absence of the protective allele of rs13207033 was strongly associated with RA when compared to carriage of none [OR of 1.86 (95% CI) (1.51-2.29)]. This equates to an effect size of 1.50 (95% CI 1.21-1.85)

{{PMID Auto
|PMID=19292917
|Title=Analysis of TNFAIP3, a feedback inhibitor of nuclear factor-kappaB and the neighbor intergenic 6q23 region in rheumatoid arthritis susceptibility
|OA=1
}}

{{omim
|id=180300
|rsnum=13207033
}}

{{PMID Auto
|PMID=19674979
|Title=Overlap of disease susceptibility loci for rheumatoid arthritis and juvenile idiopathic arthritis.
|OA=1
}}

{{PMID Auto
|PMID=20444755
|Title=Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment.
|OA=1
}}

{{PMID Auto
|PMID=22328738
|Title=Comprehensive assessment of rheumatoid arthritis susceptibility loci in a large psoriatic arthritis cohort.
|OA=1
}}

{{PMID Auto
|PMID=22798268
|Title=Rheumatoid arthritis-associated polymorphisms at 6q23 are associated with radiological damage in autoantibody-positive RA.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}