{{Rsnum
|rsid=13208776
|Gene=SMOC2
|Chromosome=6
|position=168540944
|Orientation=plus
|GMAF=0.1561
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=SMOC2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 11.5 | 45.1 | 43.4
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 8.8 | 91.2
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 3.7 | 96.3
| GIH | 1.0 | 24.8 | 74.3
| LWK | 0.0 | 4.5 | 95.5
| MEX | 3.4 | 25.9 | 70.7
| MKK | 0.6 | 22.4 | 76.9
| TSI | 11.9 | 37.6 | 50.5
| HapMapRevision=28
}}[[rs13208776]] is a SNP in the SPARC related modular calcium binding 2 [[SMOC2]] gene.

A genome-wide association study (GWAS) of generalized [[vitiligo]] in 32 distantly related affected patients from a remote Romanian village identified [[rs13208776]] as highly associated with the disorder, at an odds ratio of 7.445 (CI: 3.5-15.3, p=8x10e-8) and a population attributable risk of 28.{{PMID|19890347|OA=1
}}

{{PMID Auto
|PMID=20965805
|Title=SMOC2 gene variant and the risk of vitiligo in Jordanian Arabs
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs13208776
|overall_frequency_n=13
|overall_frequency_d=128
|overall_frequency=0.101562
|n_genomes=11
|n_genomes_annotated=0
|n_haplomes=13
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23463390
|Title=Variants in PTPN22 and SMOC2 genes and the risk of thyroid disease in the Jordanian Arab population.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}