{{Rsnum
|rsid=1321172
|Gene=PDE4B
|Chromosome=1
|position=66265030
|Orientation=minus
|GMAF=0.3269
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
|Gene_s=PDE4B
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 31.9 | 46.0 | 22.1
| HCB | 4.4 | 27.7 | 67.9
| JPT | 0.9 | 15.0 | 84.1
| YRI | 3.4 | 21.1 | 75.5
| ASW | 3.5 | 45.6 | 50.9
| CHB | 4.4 | 27.7 | 67.9
| CHD | 2.8 | 32.1 | 65.1
| GIH | 15.2 | 39.4 | 45.5
| LWK | 0.9 | 27.5 | 71.6
| MEX | 5.3 | 49.1 | 45.6
| MKK | 0.6 | 18.7 | 80.6
| TSI | 29.4 | 44.1 | 26.5
| HapMapRevision=28
}}
[[rs1321172]] has been reported in a large study to be associated with [[multiple sclerosis]].

The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with this allele is 1.08 (CI 1.02-1.14). {{PMID|17660530}}

{{PharmGKB
|RSID=rs1321172
|Name_s=
|Gene_s=PDE4B
|Feature=
|Evidence=PubMed ID:17660530
|Annotation=In a replicated GWAS of U.K. and U.S. case/parent trios, this variant was shown to be associated with multiple sclerosis risk.
|Drugs=
|Drug Classes=
|Diseases=Multiple Sclerosis
|Curation Level=Curated
|PharmGKB Accession ID=PA162356173
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1321172
|overall_frequency_n=39
|overall_frequency_d=128
|overall_frequency=0.304688
|n_genomes=26
|n_genomes_annotated=0
|n_haplomes=36
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22492128
|Title=Association of SNPs rs6498169 and rs10984447 with multiple sclerosis in Saudi patients: a model of the usefulness of familial aggregates in identifying genetic linkage in a multifactorial disease.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}