{{Rsnum
|rsid=13254738
|Chromosome=8
|position=127092098
|Orientation=plus
|GMAF=0.4752
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene=PRNCR1
|Gene_s=PRNCR1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 46.2 | 38.5 | 15.4
| HCB | 4.4 | 51.1 | 44.4
| JPT | 8.9 | 53.3 | 37.8
| YRI | 11.3 | 29.0 | 59.7
| ASW | 0.0 | 0.0 | 0.0
| CHB | 4.4 | 51.1 | 44.4
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}rs13254738 increases susceptibility to Prostate cancer 1.18 times for carriers of the C allele {{PMID|17401364|OA=1
}}

{{PMID Auto
|PMID=19549807
|Title=Prostate Cancer Risk Associated Loci in African Americans
|OA=1
}}

{{PharmGKB
|RSID=rs13254738
|Name_s=
|Gene_s=SRRM1L
|Feature=
|Evidence=PubMed ID:18349290
|Annotation=A study in a series of 1,499 breast cancer cases and 1,390 controls showed an association between rs13281615 (at 8q24) and risk of breast cancer.
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Curated
|PharmGKB Accession ID=PA162565806
}}

{{PMID Auto
|PMID=21051319
|Title=Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880[T]: Results from the Los Angeles-Shanghai Case-Control Study
|OA=1
}}

{{PMID Auto
|PMID=22549899
|Title=Genetic polymorphism and prostate cancer aggressiveness: A case-only study of 1,536 GWAS and candidate SNPs in African-Americans and European-Americans
|OA=1
}}

{{PMID Auto
|PMID=17618282
|Title=A common genetic risk factor for colorectal and prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=18231127
|Title=8q24 and prostate cancer: association with advanced disease and meta-analysis.
|OA=1
}}

{{PMID Auto
|PMID=18360876
|Title=Chromosome 8q24 markers: risk of early-onset and familial prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=18373104
|Title=Genetic variants in the 8q24 locus and risk of testicular germ cell tumors.
}}

{{PMID Auto
|PMID=18535017
|Title=Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.
|OA=1
}}

{{PMID Auto
|PMID=18577746
|Title=Multiple loci with different cancer specificities within the 8q24 gene desert.
|OA=1
}}

{{PMID Auto
|PMID=19366828
|Title=Evaluation of 8q24 and 17q risk loci and prostate cancer mortality.
|OA=1
}}

{{PMID Auto
|PMID=19549893
|Title=Evaluation of the 8q24 prostate cancer risk locus and MYC expression.
|OA=1
}}

{{PMID Auto
|PMID=19602258
|Title=Significance of common variants on human chromosome 8q24 in relation to the risk of prostate cancer in native Japanese men.
|OA=1
}}

{{PMID Auto
|PMID=19690179
|Title=Functional and clinical significance of variants localized to 8q24 in colon cancer.
}}

{{PMID Auto
|PMID=20039378
|Title=Estimation of genotype relative risks from pedigree data by retrospective likelihoods.
|OA=1
}}

{{PMID Auto
|PMID=22382457
|Title=Racial disparities in the association between variants on 8q24 and prostate cancer: a systematic review and meta-analysis.
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs13254738
|overall_frequency_n=52
|overall_frequency_d=124
|overall_frequency=0.419355
|n_genomes=35
|n_genomes_annotated=0
|n_haplomes=42
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=22923026
  |Trait=Prostate cancer
  |Title=Evaluating genetic risk for prostate cancer among Japanese and Latinos.
  |RiskAllele=C
  |Pval=4E-10
  |OR=1.59
  |ORtxt=[1.38-1.84]
  |OA=1
}}

{{PMID Auto
|PMID=22848671
|Title=Association of eleven common, low-penetrance colorectal cancer susceptibility genetic variants at six risk loci with clinical outcome.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}