{{Rsnum
|rsid=13266634
|Gene=SLC30A8
|Chromosome=8
|position=117172544
|Orientation=plus
|ReferenceAllele=C
|MissenseAllele=T
|GMAF=0.2824
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=SLC30A8
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 56.6 | 38.9 | 4.4
| HCB | 29.9 | 46.7 | 23.4
| JPT | 30.1 | 50.4 | 19.5
| YRI | 88.4 | 10.9 | 0.7
| ASW | 66.7 | 31.6 | 1.8
| CHB | 29.9 | 46.7 | 23.4
| CHD | 27.5 | 52.3 | 20.2
| GIH | 61.4 | 32.7 | 5.9
| LWK | 89.1 | 10.9 | 0.0
| MEX | 62.1 | 32.8 | 5.2
| MKK | 91.0 | 8.4 | 0.6
| TSI | 56.4 | 36.6 | 6.9
| HapMapRevision=28
}}[[rs13266634]] is a SNP in the zinc transporter protein member 8 [[SLC30A8]] gene that has primarily been associated with [[type-2 diabetes]] in several studies. This SNP is also known as the Arg325Trp or R325W variant; the (C) allele encodes the arginine (R), and the (T) allele encodes the tryptophan (W).

{{PMID|18162508}} significantly associated p = 0.0073; in 1,630 Japanese subjects with [[type-2 diabetes]] and in 1,064 controls

The major alleles of the [[SLC30A8]] SNP [[rs13266634]] and the HHEX SNP [[rs7923837]] associate with reduced insulin secretion, but not with insulin resistance. {{PMID|17786204|OA=1
}}

{{PMID|18324385}} 46% of European non-diabetic offspring of [[type-2 diabetes]] patients are [[rs13266634]](C;C) homozygotes; they are diabetes-prone and characterised by a 19% decrease in first-phase insulin release following an intravenous glucose load.

* Note: this SNP, [[rs13266634]], is not represented on the Affymetrix 5.0 chip. Since it is also in an area of high recombination, it also lacks a proxy on the Affy chip and thus could not have been detected in the large genome-wide [[type-2 diabetes]] study performed by the Wellcome Trust Consortium. {{PMID|17554300|OA=1
}}

{{PMID|18437351}} 1,638 [[type-2 diabetes]] patients and 1,858 controls
*[[rs13266634]] in SLC30A8 (OR 1.20, 95% CI: 1.09-1.33, p = 3.9 x 10(-4)). 

{{PMID|18548167|OA=1
}} [[rs13266634]](C) allele is associated with younger age of onset of [[type-1 diabetes]]

{{PMID|19033397|OA=1
}} This SNP was confirmed to be associated with [[type-2 diabetes]] in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

[http://blog.23andme.com/2008/12/18/snpwatch-genetic-variants-linked-to-long-term-measure-of-blood-sugar-level/ spitotoon] associated with blood sugar levels (glycated hemoglobin levels) [[rs13266634]](C)

{{ neighbor
| rsid = 3802177
| distance = 242
}}

{{GWAS Summary
|SNP=rs13266634
|PubMedID=17293876
|Condition=Type 2 diabetes
|Gene=SLC30A8
|Risk Allele=C
|pValue=6.00E-008
|OR=1.18
|95CI=0.69-1.67
}}
{{PMID Auto
|PMID=19258437
|Title=A Genetic Variant in the IGF2BP2 Gene may Interact with Fetal Malnutrition on Glucose Metabolism.
|OA=1
}}
{{PMID Auto
|PMID=19096518
|Title=Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto GWAS
|PMID=19056611
|Trait=Type 2 diabetes
|Title=Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data
|RiskAllele=
|Pval=0.000007
|OR=1.18
|ORtxt=[1.10-1.27]
|OA=1
}}
{{PMID Auto GWAS
|PMID=17463246
|Trait=Type 2 diabetes
|Title=Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
|RiskAllele=C
|Pval=4.9999999999999998E-8
|OR=1.12
|ORtxt=[1.07-1.16]
}}
{{PMID Auto GWAS
|PMID=17463248
|Trait=Type 2 diabetes
|Title=A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
|RiskAllele=C
|Pval=4.9999999999999998E-8
|OR=1.12
|ORtxt=[1.07-1.16]
|OA=1
}}
{{PMID Auto GWAS
|PMID=17460697
|Trait=Type 2 diabetes
|Title=A variant in CDKAL1 influences insulin response and risk of type 2 diabetes
|RiskAllele=C
|Pval=0.0000030000000000000001
|OR=1.15
|ORtxt=[1.08-1.22]
}}
{{PMID Auto GWAS
|PMID=17463249
|Trait=Type 2 diabetes
|Title=Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
|RiskAllele=C
|Pval=5E-8
|OR=1.12
|ORtxt=[1.07-1.16]
|OA=1
}}
{{PMID Auto GWAS
|PMID=19401414
|Trait=Type 2 diabetes
|Title=Confirmation of multiple risk loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population
|RiskAllele=C
|Pval=2E-14
|OR=1.22
|ORtxt=[1.16-1.28]
|OA=1
}}

{{omim
|id=611145
|desc=SOLUTE CARRIER FAMILY 30 (ZINC TRANSPORTER), MEMBER 8; SLC30A8
|rsnum=13266634
}}
{{PMID Auto
|PMID=19590848
|Title=Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk
}}
{{PMID Auto
|PMID=19655390
|Title=Zn(2+)-transporter-8: A dual role in diabetes
}}
{{PMID Auto
|PMID=19741166
|Title=Common Genetic Determinants of Glucose Homeostasis in Healthy Children: The European Youth Heart Study (EYHS)
|OA=1
}}
{{PMID Auto GWAS
|PMID=19734900
|Trait=Type 2 diabetes and other traits
|Title=Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia
|RiskAllele=C
|Pval=8E-8
|OR=1.16
|ORtxt=[1.10-1.22]
}}

{{PharmGKB
|RSID=rs13266634
|Name_s=
|Gene_s=SLC30A8
|Feature=
|Evidence=PubMed ID:19056611; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome wide association data. (Initial Sample Size: 1,924 cases, 2,938 controls; Replication Sample Size: 3,757 cases, 5,346 controls); (Region: 8q24.11; Reported Gene(s): SLC30A8; Risk Allele: rs13266634-?); (p-value= 0.000007).This variant is associated with Type 2 diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740300
}}

{{PMID Auto
|PMID=20167458
|Title=SLC30A8 polymorphism and type 2 diabetes risk: Evidence from 27 study groups
}}

{{PMID Auto
|PMID=20802253
|Title=Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion
|OA=1
}}
{{PMID Auto
|PMID=20839289
|Title=Impact of repeated measures and sample selection on genome-wide association studies of fasting glucose
|OA=1
}}

{{PharmGKB
|RSID=rs13266634
|Name_s=SLC30A8:Arg325Trp; SLC30A8:R325W
|Gene_s=SLC30A8
|Feature=
|Evidence=PubMed ID:17786204; PubMed ID:18162508; PubMed ID:18264689; PubMed ID:18324385
|Annotation=This variant has been reported to be significantly associated with type 2 diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA161749011
}}

{{PharmGKB
|RSID=rs13266634
|Name_s=
|Gene_s=SLC30A8
|Feature=
|Evidence=PubMed ID:17463249
|Annotation=rs13266634 is associated with susceptibility to Type 2 Diabetes. The association has been noted in two case-control studies of UK subjects as well as in two other large case-control studies.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162191339
}}

{{PharmGKB
|RSID=rs13266634
|Name_s=
|Gene_s=SLC30A8
|Feature=
|Evidence=PubMed ID:17463248
|Annotation=In a large Finnish case-control GWAS, rs13266634 was found to be associated with susceptibility to Type 2 Diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA162191360
}}

{{PharmGKB
|RSID=rs13266634
|Name_s=
|Gene_s=SLC30A8
|Feature=
|Evidence=PubMed ID:17293876; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: A genome-wide association study identifies novel risk loci for type 2 diabetes (Initial Sample Size: 1,380 cases, 1,323 controls; Replication Sample Size: 2,617 cases, 2,894 controls; Risk Allele: rs13266634-C).
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus; Diabetes Mellitus, Type 2
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356600
}}
{{PMID Auto
|PMID=21036910
|Title=Association of a fasting glucose genetic risk score with subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
|OA=1
}}
{{PMID Auto
|PMID=21131091
|Title=Association between rs13266634 C/T polymorphisms of solute carrier family 30 member 8 (SLC30A8) and type 2 diabetes, impaired glucose tolerance, type 1 diabetes-A meta-analysis
}}

{{omim
|id=611145
|rsnum=13266634
|variant=0001
}}

{{PMID Auto
|PMID=21510814
|Title=Association of Genetic Variations in TCF7L2, SLC30A8, HHEX, LOC387761, and EXT2 with Type 2 Diabetes Mellitus in Tunisia
}}

{{PMID Auto
|PMID=22069278
|Title=Mapping of conformational autoantibody epitopes in ZNT8
|OA=1
}}

{{PMID Auto
|PMID=22569928
|Title=Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus
|OA=1
}}

{{PMID Auto
|PMID=22584884
|Title=The Effect of Type 2 Diabetes Risk Loci on Insulin Requirements in Type 1 Diabetes
}}

{{ClinVar
|rsid=13266634
|Reversed=0
|FwdREF=C
|FwdALT=T
|REF=C
|ALT=T
|RSPOS=118184783
|CHROM=8
|GMAF=0.2821
|dbSNPBuildID=121
|SSR=0
|SAO=1
|VP=0x050168000000150517130101
|GENEINFO=SLC30A8:169026
|GENE_NAME=SLC30A8
|GENE_ID=169026
|WGT=0
|VC=SNV
|CLNALLE=1
|CLNHGVS=NC_000008.10:g.118184783C>T
|CLNORIGIN=1
|CLNSIG=255
|Tags=PM;PMC;SLO;VLD;G5;HD;GNO;KGPhase1;KGPROD;OTHERKG;PH3;LSD;MTP;OM
|CAF=0.7176; 0.2824
|CLNACC=RCV000001055.1
|CLNDBN=Diabetes mellitus type 2
|CLNDSDB=MedGen:OMIM:SNOMED_CT
|CLNDSDBID=C0011860:125853:44054006
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=611145.0001
|COMMON=1
|Disease=Diabetes mellitus type 2
}}

{{PMID Auto
|PMID=17786212
|Title=Heterogeneity in meta-analyses of genome-wide association investigations.
|OA=1
}}

{{PMID Auto
|PMID=17928989
|Title=Variations in the HHEX gene are associated with increased risk of type 2 diabetes in the Japanese population.
}}

{{PMID Auto
|PMID=17971426
|Title=Polymorphisms in the IDE-KIF11-HHEX gene locus are reproducibly associated with type 2 diabetes in a Japanese population.
}}

{{PMID Auto
|PMID=18162509
|Title=A polymorphism in the zinc transporter gene SLC30A8 confers resistance against posttransplantation diabetes mellitus in renal allograft recipients.
}}

{{PMID Auto
|PMID=18210030
|Title=Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study.
}}

{{PMID Auto
|PMID=18224312
|Title=Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
|OA=1
}}

{{PMID Auto
|PMID=18400535
|Title=A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population.
}}

{{PMID Auto
|PMID=18426861
|Title=Association analysis of type 2 diabetes Loci in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18443202
|Title=Association analysis in african americans of European-derived type 2 diabetes single nucleotide polymorphisms from whole-genome association studies.
|OA=1
}}

{{PMID Auto
|PMID=18461161
|Title=Post genome-wide association studies of novel genes associated with type 2 diabetes show gene-gene interaction and high predictive value.
|OA=1
}}

{{PMID Auto
|PMID=18469204
|Title=Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians.
|OA=1
}}

{{PMID Auto
|PMID=18498634
|Title=The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies.
|OA=1
}}

{{PMID Auto
|PMID=18533027
|Title=Worldwide population differentiation at disease-associated SNPs.
|OA=1
}}

{{PMID Auto
|PMID=18544707
|Title=Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.
|OA=1
}}

{{PMID Auto
|PMID=18556337
|Title=Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the diabetes prevention trial-type 1 (DPT-1).
|OA=1
}}

{{PMID Auto
|PMID=18591387
|Title=A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18591388
|Title=Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk.
|OA=1
}}

{{PMID Auto
|PMID=18598350
|Title=Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.
|OA=1
}}

{{PMID Auto
|PMID=18628523
|Title=Zinc transporter-8 gene (SLC30A8) is associated with type 2 diabetes in Chinese.
}}

{{PMID Auto
|PMID=18633108
|Title=Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
|OA=1
}}

{{PMID Auto
|PMID=18654633
|Title=Simultaneous analysis of all SNPs in genome-wide and re-sequencing association studies.
|OA=1
}}

{{PMID Auto
|PMID=18689899
|Title=Exchangeable models of complex inherited diseases.
|OA=1
}}

{{PMID Auto
|PMID=18694974
|Title=Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study.
|OA=1
}}

{{PMID Auto
|PMID=18782870
|Title=Clinical review: the genetics of type 2 diabetes: a realistic appraisal in 2008.
|OA=1
}}

{{PMID Auto
|PMID=18850084
|Title=Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes.
}}

{{PMID Auto
|PMID=18852197
|Title=Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.
|OA=1
}}

{{PMID Auto
|PMID=18991055
|Title=Association between polymorphisms in SLC30A8, HHEX, CDKN2A/B, IGF2BP2, FTO, WFS1, CDKAL1, KCNQ1 and type 2 diabetes in the Korean population.
}}

{{PMID Auto
|PMID=19002430
|Title=Type 2 diabetes-associated genetic variants discovered in the recent genome-wide association studies are related to gestational diabetes mellitus in the Korean population.
}}

{{PMID Auto
|PMID=19008344
|Title=Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.
|OA=1
}}

{{PMID Auto
|PMID=19020323
|Title=Genotype score in addition to common risk factors for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19108828
|Title=Genetic variations of solute carrier family 30 (zinc transporter) member 8 (SLC30A8) are not associated with polycystic ovary syndrome.
}}

{{PMID Auto
|PMID=19161620
|Title=An open access database of genome-wide association results.
|OA=1
}}

{{PMID Auto
|PMID=19172244
|Title=The risk allele load accelerates the age-dependent decline in beta cell function.
}}

{{PMID Auto
|PMID=19207020
|Title=Meta-analysis in genome-wide association studies.
|OA=1
}}

{{PMID Auto
|PMID=19228808
|Title=Type 2 diabetes risk alleles are associated with reduced size at birth.
|OA=1
}}

{{PMID Auto
|PMID=19279076
|Title=Genetic predisposition, Western dietary pattern, and the risk of type 2 diabetes in men.
|OA=1
}}

{{PMID Auto
|PMID=19324937
|Title=Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults.
|OA=1
}}

{{PMID Auto
|PMID=19341491
|Title=Genome-based prediction of common diseases: methodological considerations for future research.
|OA=1
}}

{{PMID Auto
|PMID=19455305
|Title=No association of multiple type 2 diabetes loci with type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19460916
|Title=Genetic architecture of type 2 diabetes: recent progress and clinical implications.
|OA=1
}}

{{PMID Auto
|PMID=19502414
|Title=Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men.
|OA=1
}}

{{PMID Auto
|PMID=19526209
|Title=Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
|OA=1
}}

{{PMID Auto
|PMID=19542200
|Title=Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variants.
|OA=1
}}

{{PMID Auto
|PMID=19602701
|Title=Underlying genetic models of inheritance in established type 2 diabetes associations.
|OA=1
}}

{{PMID Auto
|PMID=19741467
|Title=Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea.
}}

{{PMID Auto
|PMID=19862325
|Title=PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=19956108
|Title=Analysis of 55 autoimmune disease and type II diabetes loci: further confirmation of chromosomes 4q27, 12q13.2 and 12q24.13 as type I diabetes loci, and support for a new locus, 12q13.3-q14.1.
|OA=1
}}

{{PMID Auto
|PMID=19956539
|Title=How many genetic variants remain to be discovered?
|OA=1
}}

{{PMID Auto
|PMID=20017978
|Title=Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=20018041
|Title=The effect of multiple genetic variants in predicting the risk of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=20043853
|Title=Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=20049090
|Title=Association between type 2 diabetes loci and measures of fatness.
|OA=1
}}

{{PMID Auto
|PMID=20075150
|Title=Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study.
|OA=1
}}

{{PMID Auto
|PMID=20138556
|Title=Meta-analysis and functional effects of the SLC30A8 rs13266634 polymorphism on isolated human pancreatic islets.
}}

{{PMID Auto
|PMID=20144318
|Title=A strategy for analyzing gene-nutrient interactions in type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=20144327
|Title=A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.
|OA=1
}}

{{PMID Auto
|PMID=20161779
|Title=Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort.
|OA=1
}}

{{PMID Auto
|PMID=20351753
|Title=A low-risk ZnT-8 allele (W325) for post-transplantation diabetes mellitus is protective against cyclosporin A-induced impairment of insulin secretion.
}}

{{PMID Auto
|PMID=20424228
|Title=Impact of common variants of PPARG, KCNJ11, TCF7L2, SLC30A8, HHEX, CDKN2A, IGF2BP2, and CDKAL1 on the risk of type 2 diabetes in 5,164 Indians.
|OA=1
}}

{{PMID Auto
|PMID=20509872
|Title=Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=20532014
|Title=The epidemiology of diabetes in Korea: from the economics to genetics.
|OA=1
}}

{{PMID Auto
|PMID=20550665
|Title=Association study of genetic variants in eight genes/loci with type 2 diabetes in a Han Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=20554072
|Title=Gestational diabetes mellitus screening based on the gene chip technique.
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
|PMID=20809084
|Title=Association analysis of SLC30A8 rs13266634 and rs16889462 polymorphisms with type 2 diabetes mellitus and repaglinide response in Chinese patients.
}}

{{PMID Auto
|PMID=20836749
|Title=Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes.
}}

{{PMID Auto
|PMID=21278902
|Title=Genetic risk profiling for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=21283728
|Title=Genetic variants of diabetes risk and incident cardiovascular events in chronic coronary artery disease.
|OA=1
}}

{{PMID Auto
|PMID=21437630
|Title=Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population.
}}

{{PMID Auto
|PMID=21604969
|Title=Relationship between ZnT8Ab, the SLC30A8 gene and disease progression in children with newly diagnosed type 1 diabetes.
}}

{{PMID Auto
|PMID=21779873
|Title=Association of the SLC30A8 missense polymorphism R325W with proinsulin levels at baseline and after lifestyle, metformin or troglitazone intervention in the Diabetes Prevention Program.
|OA=1
}}

{{PMID Auto
|PMID=22377714
|Title=Impact of common type 2 diabetes risk gene variants on future type 2 diabetes in the non-diabetic population in Korea.
}}

{{PMID Auto
|PMID=22686132
|Title=Association between autoantibodies to the Arginine variant of the Zinc transporter 8 (ZnT8) and stimulated C-peptide levels in Danish children and adolescents with newly diagnosed type 1 diabetes.
}}

{{GET Evidence
|gene=SLC30A8
|aa_change=Arg325Trp
|aa_change_short=R325W
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs13266634
|overall_frequency_n=2446
|overall_frequency_d=10758
|overall_frequency=0.227366
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=18
|n_articles=2
|n_articles_annotated=2
|in_omim=Y
|in_gwas=Y
|in_pharmgkb=Y
|nblosum100=7
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23194113
|Title=Zinc transporter type 8 autoantibodies (ZnT8A): prevalence and phenotypic associations in latent autoimmune diabetes in adults and type 1 diabetes diagnosed &gt;35 years
}}

{{PMID Auto
|PMID=22749234
|Title=Contribution of common variants of ENPP1, IGF2BP2, KCNJ11, MLXIPL, PPARγ, SLC30A8 and TCF7L2 to the risk of type 2 diabetes in Lebanese and Tunisian Arabs
}}

{{PMID Auto
|PMID=24449369
|Title=SLC30A8 gene polymorphism (rs13266634 C/T) and type 2 diabetes mellitus in south Iranian population
}}

{{PMID Auto
|PMID=24499956
|Title=SLC30A8 rs13266634 polymorphism is related to a favorable cardiometabolic lipid profile in HIV/hepatitis C virus-coinfected patients
}}

{{PMID Auto
|PMID=22447136
|Title=ZnT8 and type 1 diabetes.
}}

{{PMID Auto
|PMID=22778022
|Title=No association between the type 2 diabetes mellitus susceptibility gene, SLC30A8 and schizophrenia in a Chinese population.
}}

{{PMID Auto
|PMID=22923468
|Title=Contribution of common genetic variation to the risk of type 2 diabetes in the Mexican Mestizo population.
|OA=1
}}

{{PMID Auto
|PMID=23061550
|Title=Prevalence of ZnT8 antibody in relation to phenotype and SLC30A8 polymorphism in adult autoimmune diabetes: results from the HUNT study, Norway.
}}

{{PMID Auto
|PMID=23126564
|Title=Antigenicity and epitope specificity of ZnT8 autoantibodies in type 1 diabetes.
}}

{{PMID Auto
|PMID=23298195
|Title=Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk and diabetic nephropathy in the Chinese She population.
}}

{{PMID Auto
|PMID=23334806
|Title=Systematic identification of interaction effects between genome- and environment-wide associations in type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=23458876
|Title=ACE I/D and MTHFR C677T polymorphisms are significantly associated with type 2 diabetes in Arab ethnicity: a meta-analysis.
}}

{{PMID Auto
|PMID=23462794
|Title=Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}