{{Rsnum
|rsid=13281615
|Chromosome=8
|position=127343372
|Orientation=plus
|GMAF=0.4826
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=LOC101930033
|Gene_s=LOC101930033
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 32.3 | 44.6 | 23.1
| HCB | 18.2 | 50.0 | 31.8
| JPT | 15.6 | 46.7 | 37.8
| YRI | 39.7 | 36.5 | 23.8
| ASW | 0.0 | 0.0 | 0.0
| CHB | 18.2 | 50.0 | 31.8
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}{{PMID|18437204|OA=1
}} [[breast cancer]]
*[[rs13281615]] in 8q24 was stronger for ER-positive, PR-positive, and low grade tumors (P = 0.001, 0.011 and 10(-4), respectively) and improvement in survival after diagnosis (per-allele HR = 0.90 (0.83-0.97).

{{PMID|19005751}} [[rs13281615]] confirmed in 988 sporadic breast cancer cases and 1,016 controls from the West of Ireland to be associated with increased risk (odds ratio 1.17, p(allelic) = 1.8 x 10e-2) for [[breast cancer]]

{{GWAS Summary
|SNP=rs13281615
|PubMedID=17529967
|Condition=Breast cancer
|Gene=Intergenic
|Risk Allele=T
|pValue=5.00E-012
|OR=1.08
|95CI=1.05-1.11
|OA=1
}}

{{omim
|desc=BREAST CANCER
|id=114480
|rsnum=13281615
}}
{{PMID Auto
|PMID=19656774
|Title=Common variants in LSP1, 2q35 and 8q24 and breast cancer risk for BRCA1 and BRCA2 mutation carriers
|OA=1
}}

{{PharmGKB
|RSID=rs13281615
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17529967; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Genome-wide association study identifies novel breast cancer susceptibility loci (Initial Sample Size: 390 cases, 364 controls; Replication Sample Size: 26,646 cases, 24,889 controls; Risk Allele: rs13281615-T).
|Drugs=
|Drug Classes=
|Diseases=Breast Neoplasms
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356621
}}

{{PMID Auto
|PMID=20145138
|Title=Common genetic variants associated with breast cancer and mammographic density measures that predict disease
}}
{{PMID Auto
|PMID=20054709
|Title=Birth weight, breast cancer susceptibility loci, and breast cancer risk
}}
{{PMID Auto
|PMID=20699374
|Title=Evaluation of Breast Cancer Susceptibility Loci in Chinese Women
|OA=1
}}
{{PMID Auto
|PMID=21051319
|Title=Risk of Urinary Bladder Cancer is Associated with 8q24 Variant rs9642880[T]: Results from the Los Angeles-Shanghai Case-Control Study
|OA=1
}}
{{PMID Auto
|PMID=21197568
|Title=Risk of genome-wide association study newly identified genetic variants for breast cancer in Chinese women of Heilongjiang Province
}}

{{PMID Auto
|PMID=21445572
|Title=Genetic polymorphisms and breast cancer risk: evidence from meta-analyses, pooled analyses, and genome-wide association studies
}}

{{PMID Auto
|PMID=21791674
|Title=Interactions Between Genetic Variants and Breast Cancer Risk Factors in the Breast and Prostate Cancer Cohort Consortium
|OA=1
}}

{{PMID Auto
|PMID=21814516
|Title=A Functional Variant at a Prostate Cancer Predisposition Locus at 8q24 Is Associated with PVT1 Expression
|OA=1
}}

{{PMID Auto
|PMID=22087758
|Title=Single nucleotide polymorphisms associated with risk for contralateral breast cancer in the Women's Environment, Cancer and Radiation Epidemiology (WECARE) study
|OA=1
}}

{{PMID Auto
|PMID=22726230
|Title=Interactive effect of genetic susceptibility with height, body mass index, and hormone replacement therapy on the risk of breast cancer
|OA=1
}}

{{PMID Auto
|PMID=17618282
|Title=A common genetic risk factor for colorectal and prostate cancer.
|OA=1
}}

{{PMID Auto
|PMID=17997823
|Title=Clinical correlates of low-risk variants in FGFR2, TNRC9, MAP3K1, LSP1 and 8q24 in a Dutch cohort of incident breast cancer cases.
|OA=1
}}

{{PMID Auto
|PMID=18224312
|Title=Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment.
|OA=1
}}

{{PMID Auto
|PMID=18349290
|Title=Association of genetic variants at 8q24 with breast cancer risk.
}}

{{PMID Auto
|PMID=18535017
|Title=Pooled analysis of genetic variation at chromosome 8q24 and colorectal neoplasia risk.
|OA=1
}}

{{PMID Auto
|PMID=18577746
|Title=Multiple loci with different cancer specificities within the 8q24 gene desert.
|OA=1
}}

{{PMID Auto
|PMID=18612136
|Title=Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18625567
|Title=Association of chromosomal locus 8q24 and risk of prostate cancer: a hospital-based study of German patients treated with brachytherapy.
}}

{{PMID Auto
|PMID=18681954
|Title=Breast cancer susceptibility loci and mammographic density.
|OA=1
}}

{{PMID Auto
|PMID=18704501
|Title=Comprehensive resequence analysis of a 136 kb region of human chromosome 8q24 associated with prostate and colon cancers.
|OA=1
}}

{{PMID Auto
|PMID=18708391
|Title=Breast cancer risk polymorphisms and interaction with ionizing radiation among U.S. radiologic technologists.
|OA=1
}}

{{PMID Auto
|PMID=18772892
|Title=Can genes for mammographic density inform cancer aetiology?
|OA=1
}}

{{PMID Auto
|PMID=18785201
|Title=Novel breast cancer risk alleles and endometrial cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=18973230
|Title=Breast cancer susceptibility alleles and ovarian cancer risk in 2 study populations.
|OA=1
}}

{{PMID Auto
|PMID=19088016
|Title=Genetic susceptibility loci for breast cancer by estrogen receptor status.
|OA=1
}}

{{PMID Auto
|PMID=19094228
|Title=The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer.
|OA=1
}}

{{PMID Auto
|PMID=19304784
|Title=Association between invasive ovarian cancer susceptibility and 11 best candidate SNPs from breast cancer genome-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=19454617
|Title=Genetic variation in the chromosome 17q23 amplicon and breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=19528667
|Title=Association of chromosome 8q variants with prostate cancer risk in Caucasian and Hispanic men.
|OA=1
}}

{{PMID Auto
|PMID=19567422
|Title=Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042.
|OA=1
}}

{{PMID Auto
|PMID=19639606
|Title=Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.
|OA=1
}}

{{PMID Auto
|PMID=20133699
|Title=Long-range enhancers on 8q24 regulate c-Myc.
|OA=1
}}

{{PMID Auto
|PMID=20146796
|Title=Familial relative risks for breast cancer by pathological subtype: a population-based cohort study.
|OA=1
}}

{{PMID Auto
|PMID=20237344
|Title=Performance of common genetic variants in breast-cancer risk models.
|OA=1
}}

{{PMID Auto
|PMID=20484103
|Title=Genetic and clinical predictors for breast cancer risk assessment and stratification among Chinese women.
|OA=1
}}

{{PMID Auto
|PMID=20605201
|Title=Gene-environment interactions in 7610 women with breast cancer: prospective evidence from the Million Women Study.
|OA=1
}}

{{PMID Auto
|PMID=21596841
|Title=Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association Consortium.
|OA=1
}}

{{PMID Auto
|PMID=22045194
|Title=Combined effect of low-penetrant SNPs on breast cancer risk.
|OA=1
}}

{{PMID Auto
|PMID=22160591
|Title=A genetic risk predictor for breast cancer using a combination of low-penetrance polymorphisms in a Japanese population.
}}

{{PMID Auto
|PMID=22532573
|Title=The role of genetic breast cancer susceptibility variants as prognostic factors.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs13281615
|overall_frequency_n=58
|overall_frequency_d=126
|overall_frequency=0.460317
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=46
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23565189
|Title=Single Nucleotide Polymorphism 8q24 rs13281615 and Risk of Breast Cancer: Meta-Analysis of More than 100,000 Cases
|OA=1
}}

{{PMID Auto
|PMID=23717390
|Title=Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm
|OA=1
}}

{{PMID Auto
|PMID=24171766
|Title=Common low-penetrance risk variants associated with breast cancer in Polish women
}}

{{PMID Auto GWAS
  |PMID=23535729
  |Trait=Breast cancer
  |Title=Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
  |RiskAllele=G
  |Pval=1E-27
  |OR=1.09
  |ORtxt=[1.07-1.12]
  |OA=1
}}

{{PMID Auto
|PMID=22910930
|Title=Genome-Wide Association Studies (GWAS) breast cancer susceptibility loci in Arabs: susceptibility and prognostic implications in Tunisians.
|OA=1
}}

{{PMID Auto
|PMID=22965832
|Title=Association of common genetic variants with breast cancer risk and clinicopathological characteristics in a Chinese population.
}}

{{PMID Auto
|PMID=23292077
|Title=Association of 8q24 rs13281615A > G polymorphism with breast cancer risk: evidence from 40,762 cases and 50,380 controls.
}}

{{PMID Auto
|PMID=23577780
|Title=Associations between single-nucleotide polymorphisms and epidural ropivacaine consumption in patients undergoing breast cancer surgery.
}}

{{PMID Auto
|PMID=24780616
|Title=Frequent Mutation of rs13281615 and Its Association with PVT1 Expression and Cell Proliferation in Breast Cancer
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}