{{Rsnum
|rsid=13306435
|Gene=IL6
|Chromosome=7
|position=22731420
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=A
|GMAF=0.0303
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;T)
|geno3=(T;T)
|Gene_s=IL6
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;T)
| geno3=(T;T)
| CEU | 0.0 | 0.0 | 100.0
| HCB | 0.0 | 2.3 | 97.7
| JPT | 0.0 | 6.8 | 93.2
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 0.0 | 2.3 | 97.7
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

A haplotype of the [[IL6]] gene appears to be overrepresented in [[sciatica]] patients.[PMID 15733644, PMID 18321738]. The haplotype consists of SNPs [[rs1800797]]-[[rs1800796]]- [[rs1800795]]-[[rs13306435]].

{{PMID Auto
|PMID=18496509
|Title=An IL-6 haplotype on human chromosome 7p21 confers risk for impaired renal function in type 2 diabetic patients.
|OA=1
}}

{{PMID Auto
|PMID=19164257
|Title=Effects of interleukin-6 T15A single nucleotide polymorphism on baseline peritoneal solute transport rate in incident peritoneal dialysis patients.
}}

{{PMID Auto
|PMID=19387461
|Title=Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection.
|OA=1
}}

{{PMID Auto
|PMID=19503017
|Title=Genetic ancestry modifies pharmacogenetic gene-gene interaction for asthma.
|OA=1
}}

{{GET Evidence
|gene=IL6
|aa_change=Asp162Glu
|aa_change_short=D162E
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs13306435
|overall_frequency_n=82
|overall_frequency_d=10758
|overall_frequency=0.00762223
|n_genomes=2
|n_genomes_annotated=0
|n_haplomes=2
|n_articles=0
|n_articles_annotated=0
|nblosum100=-2
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22714907
|Title=IL6 gene polymorphisms and susceptibility to colorectal cancer: a meta-analysis and review.
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}