{{Rsnum
|rsid=1333048
|Chromosome=9
|position=22125348
|Orientation=plus
|GMAF=0.4541
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|Summary=coronary artery disease risk and periodontitis
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 28.3 | 49.6 | 22.1
| HCB | 23.4 | 53.3 | 23.4
| JPT | 23.9 | 46.9 | 29.2
| YRI | 57.8 | 36.7 | 5.4
| ASW | 35.1 | 56.1 | 8.8
| CHB | 23.4 | 53.3 | 23.4
| CHD | 29.4 | 44.0 | 26.6
| GIH | 24.8 | 54.5 | 20.8
| LWK | 50.5 | 42.2 | 7.3
| MEX | 20.7 | 55.2 | 24.1
| MKK | 53.2 | 40.4 | 6.4
| TSI | 18.6 | 52.9 | 28.4
| HapMapRevision=28
}}[[rs1333048]] increases susceptibility to [[coronary artery disease]] 1.30 times for heterozygotes (AC) and 1.54 times for homozygotes (CC) {{PMID|17478681|OA=1
}}

{{PMID|19214202|OA=1
}} rs1333048 2x risk for [[periodontitis]] and a confirmation of [[coronary heart disease]]

[http://blog.23andme.com/2009/06/03/study-draws-genetic-link-between-gum-cardiovascular-disease/ 23andMe blog] 

{{Report GE
|PubMed=17478681
|Source=journal
|AffyProbeset=SNP_A-1855630
|AffyOrientation=reverse
|AlleleA=G
|AlleleB=T
|onGW5=1
|rsid=1333048
|ancestral=A
|RiskPopulation=CEU
|RiskAllele=C
|CaseFreq=
|ControlFreq=
|OddsRatioHet=1.30
|OddsRatioHom=1.54
|OddsRatioAll=1.23
|Disease=Coronary artery disease
|DiseaseSymbol=CAD
|OA=1
}}

{{ neighbor
| rsid = 10757278
| distance = 870
}}
{{ neighbor
| rsid = 1333049
| distance = 156
}}

{{PMID Auto
|PMID=20696043
|Title=Replication of the association of chromosomal region 9p21.3 with generalized aggressive periodontitis (gAgP) using an independent case-control cohort
|OA=1
}}

{{omim
|id=170650
|rsnum=1333048
}}

{{PMID Auto
|PMID=22430189
|Title=Replication of relevant SNPs associated with cardiovascular disease susceptibility obtained from GWAs in a case-control study in a Canarian population
|OA=1
}}

{{PMID Auto
|PMID=18987759
|Title=Genetic testing for atherosclerosis risk: inevitability or pipe dream?
|OA=1
}}

{{PMID Auto
|PMID=19578366
|Title=Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
|OA=1
}}

{{PMID Auto
|PMID=23587006
|Title=Validation of reported genetic risk factors for periodontitis in a large-scale replication study
}}

{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}