{{Rsnum
|rsid=13333226
|Gene=UMOD
|Chromosome=16
|position=20354332
|Orientation=plus
|GMAF=0.1965
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=UMOD
}}[[rs13333226]] is a SNP in the 5' region of uromodulin [[UMOD]] gene.

A large GWAS study ultimately totaling over 20,000 cases and almost as many controls concluded that, compared to the far more common allele, the rarer [[rs13333226]](G) allele is associated with a (slightly) lower risk of [[hypertension]] (odds ratio 0.87, CI: 0.84-0.91) as well as a 7.7% reduction per allele for risk of cardiovascular events after adjusting for age, sex, BMI, and smoking status (hazard ratio?0.923, CI: 0.860-0.991; p?=?0.027).
{{PMID|21082022|OA=1
}}

{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 67.3 | 30.1 | 2.7
| HCB | 78.8 | 20.4 | 0.7
| JPT | 91.2 | 8.8 | 0.0
| YRI | 38.1 | 46.9 | 15.0
| ASW | 40.4 | 52.6 | 7.0
| CHB | 78.8 | 20.4 | 0.7
| CHD | 89.9 | 10.1 | 0.0
| GIH | 57.4 | 34.7 | 7.9
| LWK | 47.3 | 43.6 | 9.1
| MEX | 62.1 | 36.2 | 1.7
| MKK | 38.5 | 50.0 | 11.5
| TSI | 70.6 | 26.5 | 2.9
| HapMapRevision=28
}}

{{PMID Auto
|PMID=19465746
|Title=Uromodulin mutations causing familial juvenile hyperuricaemic nephropathy lead to protein maturation defects and retention in the endoplasmic reticulum.
|OA=1
}}

{{PMID Auto
|PMID=21738052
|Title=Uromodulin gene variant is associated with type 2 diabetic nephropathy.
}}

[[High Blood Pressure (Hypertension)]]

[[Kidney Disease]]

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}