{{Rsnum
|rsid=13361189
|Chromosome=5
|position=150843825
|Orientation=plus
|GMAF=0.2746
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 0.0 | 7.1 | 92.9
| HCB | 16.9 | 47.8 | 35.3
| JPT | 17.0 | 42.0 | 41.1
| YRI | 24.0 | 53.4 | 22.6
| ASW | 17.9 | 48.2 | 33.9
| CHB | 16.9 | 47.8 | 35.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 2.0 | 25.3 | 72.7
| LWK | 18.3 | 41.3 | 40.4
| MEX | 3.4 | 24.1 | 72.4
| MKK | 9.0 | 43.6 | 47.4
| TSI | 1.0 | 25.0 | 74.0
| HapMapRevision=28
}}
[[rs13361189]] is a SNP in the [[IRGM]] gene.

A study including 557 [[Crohn's disease]] (CD) patients, 425 ulcerative colitis (UC) patients, and 672 ethnically matched Spanish controls as well as a meta-analysis concluded that [[rs13361189]](C) was associated with CD (p=1.07 x 10(-19), pooled odds ratio 1.34) and UC (p=0.0069, pooled odds ratio 1.16).{{PMID|19491842}} 

[http://blog.23andme.com/2008/08/25/researchers-find-biological-basis-for-crohns-association/ 23andMe blog] Each copy of a C at rs13361189 increases a person's risk of developing [[Crohn's disease]] 1.33 times compared to someone with two copies of a T

{{GWAS Summary
|SNP=rs13361189
|PubMedID=17554261
|Condition=Crohn's disease
|Gene=IRGM
|Risk Allele=
|pValue=2.00E-010
|OR=1.38
|95CI=1.15-1.66
|OA=1
}}

{{omim
|desc=INFLAMMATORY BOWEL DISEASE 19; IBD19
|id=612278
|rsnum=13361189
}}

{{omim
|desc=IMMUNITY-RELATED GTPase FAMILY, M; IRGM
|id=608212
|rsnum=13361189
}}

{{PharmGKB
|RSID=rs13361189
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:17554261; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility (Initial Sample Size: 1,748 cases, 2,938 controls; Replication Sample Size: 1,182 cases, 2,024 controls). This variant is associated with Crohn's disease.
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356573
}}

{{PMID Auto
|PMID=19953089
|Title=Differences in genetic background between active smokers, passive smokers, and non-smokers with Crohn's disease
}}

{{PMID Auto
|PMID=22713085
|Title=IRGM gene polymorphisms and risk of gastric cancer
}}

{{PMID Auto
|PMID=18438406
|Title=Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=18580884
|Title=Confirmation of association of IRGM and NCF4 with ileal Crohn's disease in a population-based cohort.
}}

{{PMID Auto
|PMID=19140132
|Title=Unbiased estimation of odds ratios: combining genomewide association scans with replication studies.
|OA=1
}}

{{PMID Auto
|PMID=19165925
|Title=Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=19750224
|Title=Autophagy gene variant IRGM -261T contributes to protection from tuberculosis caused by Mycobacterium tuberculosis but not by M. africanum strains.
|OA=1
}}

{{PMID Auto
|PMID=20106866
|Title=Independent and population-specific association of risk variants at the IRGM locus with Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=20395867
|Title=Is there a role for Crohn's disease-associated autophagy genes ATG16L1 and IRGM in formation of granulomas?
}}

{{PMID Auto
|PMID=21049557
|Title=NKX2-3 and IRGM variants are associated with disease susceptibility to IBD in Eastern European patients.
|OA=1
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{PMID Auto
|PMID=22065112
|Title=The JAK2 variant rs10758669 in Crohn's disease: altering the intestinal barrier as one mechanism of action.
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs13361189
|overall_frequency_n=22
|overall_frequency_d=108
|overall_frequency=0.203704
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=21
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=24232856
|Title=Association between Variants of the Autophagy Related Gene - IRGM and Susceptibility to Crohn's Disease and Ulcerative Colitis: A Meta-Analysis
|OA=1
}}

{{PMID Auto
|PMID=24264476
|Title=Autophagy Gene Polymorphism is Associated with Susceptibility to Leprosy by Affecting Inflammatory Cytokines
}}

{{PMID Auto
|PMID=22573572
|Title=Phenotype-genotype profiles in Crohn's disease predicted by genetic markers in autophagy-related genes (GOIA study II).
}}

{{PMID Auto
|PMID=24859836
|Title=Functional IRGM polymorphism is associated with language impairment in glioma and upregulates cytokine expressions
}}

{{PMID Auto
|PMID=25009628
|Title=IRGM rs13361189 polymorphism may contribute to susceptibility to Crohn's disease: A meta-analysis
}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}