{{Rsnum
|rsid=13393173
|Gene=LASS6
|Chromosome=2
|position=168532581
|Orientation=plus
|GMAF=0.1203
|Gene_s=CERS6
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 9.8 | 31.2 | 58.9
| HCB | 0.0 | 3.6 | 96.4
| JPT | 0.0 | 5.3 | 94.7
| YRI | 0.0 | 0.7 | 99.3
| ASW | 0.0 | 7.0 | 93.0
| CHB | 0.0 | 3.6 | 96.4
| CHD | 0.0 | 2.8 | 97.2
| GIH | 0.0 | 11.9 | 88.1
| LWK | 0.0 | 2.7 | 97.3
| MEX | 1.7 | 22.4 | 75.9
| MKK | 0.0 | 0.6 | 99.4
| TSI | 1.0 | 25.5 | 73.5
| HapMapRevision=28
}}{{PMID Auto GWAS
|PMID=18615156
|Trait=Treatment response to TNF antagonists
|Title=Genome-wide association scan identifies candidate polymorphisms associated with differential response to anti-TNF treatment in Rheumatoid Arthritis
|RiskAllele=A
|Pval=0.0000039999999999999998
|OR=NR
|ORtxt=NR
|OA=1
}}

{{PharmGKB
|RSID=rs13393173
|Name_s=
|Gene_s=LASS6
|Feature=
|Evidence=PubMed ID:18615156
|Annotation=This variant is significantly associated with the efficacy of anti-TNF treatment in rheumatoid arthritis (Adjusted P-value: 0.000004; OR: 6.8 (1.7, 40.3)). The study is a genome-wide association study using the Illumina HapMap300 SNP chip on 89 RA patients prospectively followed after beginning of anti-TNF therapy.
|Drugs=adalimumab; etanercept; infliximab
|Drug Classes=
|Diseases=Arthritis, Rheumatoid
|Curation Level=Curated
|PharmGKB Accession ID=PA162928820
}}

{{PMID Auto
|PMID=20423481
|Title=Lack of replication of genetic predictors for the rheumatoid arthritis response to anti-TNF treatments: a prospective case-only study.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs13393173
|overall_frequency_n=19
|overall_frequency_d=128
|overall_frequency=0.148438
|n_genomes=16
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}