{{Rsnum
|rsid=1343151
|Gene=IL23R
|Chromosome=1
|position=67253446
|Orientation=minus
|GMAF=0.3237
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=IL23R
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 48.7 | 37.2 | 14.2
| HCB | 92.0 | 8.0 | 0.0
| JPT | 82.3 | 16.8 | 0.9
| YRI | 9.5 | 35.4 | 55.1
| ASW | 8.8 | 64.9 | 26.3
| CHB | 92.0 | 8.0 | 0.0
| CHD | 95.4 | 4.6 | 0.0
| GIH | 71.3 | 27.7 | 1.0
| LWK | 10.9 | 40.0 | 49.1
| MEX | 58.6 | 34.5 | 6.9
| MKK | 17.3 | 57.7 | 25.0
| TSI | 44.6 | 43.6 | 11.9
| HapMapRevision=28
}}
[[rs1343151]] is one of several SNPs in the [[IL23R]] gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with [[ankylosing spondylitis]]. The odds ratio is 0.8 (p=1.0x10e-5).[PMID 17952073, PMID 18037607]

{{PMID|18647855}} rs1343151 with [[rheumatoid arthritis]] (OR=1.14 [1.06-1.22], P=4x10-4)

[[rs1343151]] was '''not''' associated with [[rheumatoid arthritis]] in a study of 1,200+ Korean patients. {{PMID|19034457}}

{{PMID|21253534|OA=1
}} A;A homozygous individuals showed a strongly reduced risk of Crohn's Disease compared those who were G;G homozygous. 

{{GWAS Summary
|SNP=rs1343151
|PubMedID=17804789
|Condition=Crohn's disease
|Gene=IL23R
|Risk Allele=
|pValue=1.00E-008
|OR=1.38
|95CI=1.23-1.53
|OA=1
}}

{{PharmGKB
|RSID=rs1343151
|Name_s=
|Gene_s=IL23R
|Feature=
|Evidence=PubMed ID:17804789; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci (Initial Sample Size: 382 trios; Replication Sample Size: 521 trios, 750 cases, 828 controls). This variant is associated with Crohn's disease. This variant is associated with Crohn's disease.
|Drugs=
|Drug Classes=
|Diseases=Crohn Disease
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356494
}}

{{PMID Auto
|PMID=21285166
|Title=Role of rs1343151 IL23R and rs3790567 IL12RB2 Polymorphisms in Biopsy-proven Giant Cell Arteritis
}}

{{PMID Auto
|PMID=22089529
|Title=Associations between interleukin-23R polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis
}}

{{PMID Auto
|PMID=17068223
|Title=A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
}}

{{PMID Auto
|PMID=17678723
|Title=Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort.
}}

{{PMID Auto
|PMID=17786191
|Title=rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants.
|OA=1
}}

{{PMID Auto
|PMID=17901940
|Title=Association analysis of IL-12B and IL-23R polymorphisms in myocardial infarction.
}}

{{PMID Auto
|PMID=18199597
|Title=The IL23R Arg381Gln non-synonymous polymorphism confers susceptibility to ankylosing spondylitis.
}}

{{PMID Auto
|PMID=18470928
|Title=IL23R haplotypes provide a large population attributable risk for Crohn's disease.
|OA=1
}}

{{PMID Auto
|PMID=19175939
|Title=IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.
|OA=1
}}

{{PMID Auto
|PMID=19306001
|Title=No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus.
}}

{{PMID Auto
|PMID=19918037
|Title=Association of interleukin 23 receptor polymorphisms with anti-topoisomerase-I positivity and pulmonary hypertension in systemic sclerosis.
|OA=1
}}

{{PMID Auto
|PMID=20116410
|Title=Polymorphisms of IL23R and Vogt-Koyanagi-Harada syndrome in a Chinese Han population.
}}

{{PMID Auto
|PMID=20454450
|Title=Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset.
|OA=1
}}

{{PMID Auto
|PMID=21253733
|Title=Interleukin-23 receptor genetic polymorphisms and ankylosing spondylitis susceptibility: a meta-analysis.
}}

{{PMID Auto
|PMID=21304977
|Title=An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.
|OA=1
}}

{{PMID Auto
|PMID=21926184
|Title=Replication of association of the interleukin 23 receptor rs1343151 variant with rheumatoid arthritis in Caucasian sample sets.
}}

{{PMID Auto
|PMID=23054009
|Title=Marked diversity of IL23R gene haplotype variants in rheumatoid arthritis comparing with Crohn's disease and ankylosing spondylitis
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1343151
|overall_frequency_n=53
|overall_frequency_d=128
|overall_frequency=0.414062
|n_genomes=35
|n_genomes_annotated=0
|n_haplomes=48
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=23053963
|Title=Associations between interleukin-23 receptor polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
}}

{{PMID Auto
|PMID=23274341
|Title=Infliximab-induced psoriasis and psoriasiform skin lesions in pediatric Crohn disease and a potential association with IL-23 receptor polymorphisms.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}