{{Rsnum
|rsid=1344706
|Gene=ZNF804A
|Chromosome=2
|position=184913701
|Orientation=plus
|GMAF=0.3453
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene_s=ZNF804A
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 13.5 | 52.3 | 34.2
| HCB | 21.9 | 50.4 | 27.7
| JPT | 39.8 | 44.2 | 15.9
| YRI | 0.0 | 4.9 | 95.1
| ASW | 1.8 | 21.1 | 77.2
| CHB | 21.9 | 50.4 | 27.7
| CHD | 23.9 | 47.7 | 28.4
| GIH | 10.9 | 33.7 | 55.4
| LWK | 0.0 | 6.4 | 93.6
| MEX | 8.8 | 49.1 | 42.1
| MKK | 0.6 | 10.3 | 89.1
| TSI | 14.7 | 54.9 | 30.4
| HapMapRevision=28
}}

[[rs1344706]] is a SNP in the [[ZNF804A]] gene, and it is probably the first SNP to have been reported as achieving genome-wide significance for psychosis.

{{PMID|20688871|OA=1
}} Reviews the literature, and concludes that [[rs1344706]] is "robustly, if modestly" associated with increased risk for [[schizophrenia]]. 

{{PMID|18677311}} A genome-wide association study of schizophrenia (479 cases, 2,937 controls) followed by additional testing and a meta-analysis concluded that the strongest evidence for association was around ZNF804A ([[rs1344706]]; p = 1.61 x 10e-7) and that the finding was strengthened when the affected phenotype included [[bipolar disorder]] (p = 9.96 x 10e-9).
{{GWAS Summary
|SNP=rs1344706
|PubMedID=18677311
|Condition=Schizophrenia
|Gene=ZNF804A
|Risk Allele=T
|pValue=2.00E-007
|OR=1.12
|95CI=
}}

{{PMID Auto
|PMID=19407193
|Title=Neural mechanisms of a genome-wide supported psychosis variant
}}

{{omim
|desc=SCHIZOPHRENIA; SCZD
|id=181500
|rsnum=1344706
}}

{{omim
|desc=SCHIZOPHRENIA 13
|id=612361
|rsnum=1344706
}}
{{PMID Auto
|PMID=19844207
|Title=Replication of association between schizophrenia and ZNF804A in the Irish Case-Control Study of Schizophrenia sample
|OA=1
}}

{{PharmGKB
|RSID=rs1344706
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19407193
|Annotation=Rs1344706, found in a separate GWAS to be associated with schizophrenia, was investigated here by Functional Magnetic Resonance Imaging. In 115 healthy German subjects, carriers of the "higher risk" allele(defined in this study as A) showed gene dosage-dependent alterations in functional coupling of dorsolateral prefrontal cortex across hemispheres and with hippocampus and also abnormal coupling of amygdala.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Curated
|PharmGKB Accession ID=PA164856914
}}

{{PMID Auto
|PMID=20603450
|Title=Psychosis Susceptibility Gene ZNF804A and Cognitive Performance in Schizophrenia
}}
{{PMID Auto
|PMID=20664580
|Title=A Schizophrenia Risk Gene, ZNF804A, Influences Neuroanatomical and Neurocognitive Phenotypes
|OA=1
}}
{{PMID Auto
|PMID=20688871
|Title=The Psychosis Susceptibility Gene ZNF804A: Associations, Functions, and Phenotypes
|OA=1
}}
{{PMID Auto
|PMID=20946959
|Title=Cognitive state and connectivity effects of the genome-wide significant psychosis variant in ZNF804A
}}

{{PharmGKB
|RSID=rs1344706
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18677311; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Identification of loci associated with schizophrenia by genome-wide association and follow-up (Initial Sample Size: 479 cases, 2,937 controls; Replication Sample Size: 6,666 cases, 9,897 controls; Risk Allele: rs1344706-T). This variant is associated with Schizophrenia.
|Drugs=
|Drug Classes=
|Diseases=Schizophrenia
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356547
}}
{{PMID Auto
|PMID=21234901
|Title=Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population
}}

{{PMID Auto
|PMID=21525856
|Title=The ZNF804A Gene: Characterization of a Novel Neural Risk Mechanism for the Major Psychoses
|OA=1
}}

{{PMID Auto
|PMID=21890790
|Title=Allelic Differences Between Han Chinese and Europeans for Functional Variants in ZNF804A and Their Association With Schizophrenia
}}

{{PMID Auto
|PMID=21276201
|Title=Bipolar disorder risk alleles in adult ADHD patients
}}

{{PMID Auto
|PMID=21988329
|Title=A Polymerase Chain Reaction-Restriction Fragment Length Polymorphism Method for Screening ZNF804A Gene Polymorphism (rs1344706) in Patients with Schizophrenia: A Significant Association
}}

{{PMID Auto
|PMID=21993378
|Title=Is the conserved mammalian region of ZNF804A locus associated with schizophrenia? A population-based genetics analysis
}}

{{PMID Auto
|PMID=22042765
|Title=Partial support for ZNF804A genotype-dependent alterations in prefrontal connectivity
}}

{{PMID Auto
|PMID=22373944
|Title=Evidence of IQ-Modulated Association Between ZNF804A Gene Polymorphism and Cognitive Function in Schizophrenia Patients
|OA=1
}}

{{PMID|19693005|OA=1
}} Executive function, neural circuitry, and genetic mechanisms in schizophrenia.

{{PMID|19721717|OA=1
}} Apoptotic engulfment pathway and schizophrenia.

{{PMID|19911060|OA=1
}} Persistence criteria for susceptibility genes for schizophrenia: a discussion from an evolutionary viewpoint.

{{PMID|20048749|OA=1
}} Expanding the range of ZNF804A variants conferring risk of psychosis.

{{PMID|20231838}} Effects of a genome-wide supported psychosis risk variant on neural activation during a theory-of-mind task.

{{PMID|20368704|OA=1
}} Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder.

{{PMID|20485477|OA=1
}} New Genetic Findings in Schizophrenia: Is there Still Room for the Dopamine Hypothesis of Schizophrenia?

{{PMID|20934520}} ZNF804A risk allele is associated with relatively intact gray matter volume in patients with schizophrenia.

{{PMID|20957649}} The impact of a genome-wide supported psychosis variant in the ZNF804A gene on memory function in schizophrenia.

{{PMID|21040459}} ZNF804A may be associated with executive control of attention.

{{PMID|21302348}} Evaluation of risk loci for schizophrenia derived from genome-wide association studies in a German population.

{{PMID|21349497}} Evidence of sex-modulated association of ZNF804A with schizophrenia.

{{PMID|21457757}} Impact on schizotypal personality trait of a genome-wide supported psychosis variant of the ZNF804A gene.

{{PMID|21767209}} ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype.

{{PMID|21810628}} Altered cortical network dynamics: a potential intermediate phenotype for schizophrenia and association with ZNF804A.

{{PMID|21892778}} The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms.

{{PMID|21911029}} Association of the ZNF804A gene polymorphism rs1344706 with white matter density changes in Chinese schizophrenia.

{{PMID|22328493}} Genome-wide supported psychosis risk variant in ZNF804A gene and impact on cortico-limbic WM integrity in schizophrenia.

{{PMID|22384243|OA=1
}} ZNF804a regulates expression of the schizophrenia-associated genes PRSS16, COMT, PDE4B, and DRD2.

{{PMID|22416237|OA=1
}} The effects of psychosis risk variants on brain connectivity: a review.

{{PMID|22425527}} Association analysis of ZNF804A (zinc finger protein 804A) rs1344706 with therapeutic response to atypical antipsychotics in first-episode Chinese patients with schizophrenia.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1344706
|overall_frequency_n=35
|overall_frequency_d=128
|overall_frequency=0.273438
|n_genomes=25
|n_genomes_annotated=0
|n_haplomes=32
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23212061
|Title=Evidence That Schizophrenia Risk Variation in the ZNF804A Gene Exerts Its Effects During Fetal Brain Development
}}

{{PMID Auto
|PMID=23351715
|Title=Investigation of the ZNF804A gene polymorphism with genetic risk for bipolar disorder in attention deficit hyperactivity disorder
|OA=1
}}

{{PMID Auto
|PMID=23562677
|Title=ZNF804A and cortical thickness in schizophrenia and bipolar disorder
}}

{{PMID Auto
|PMID=24066410
|Title=Evaluation of the relationship between the ZNF804A single nucleotide polymorphism rs1344706 A/C variant and schizophrenia subtype in Han Chinese patients
}}

{{PMID Auto
|PMID=24247043
|Title=Further Evidence for The Impact of a Genome-Wide Supported Psychosis Risk Variant in ZNF804A on The Theory of Mind Network
}}

{{PMID Auto
|PMID=24315717
|Title=Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex
}}

{{PMID Auto
|PMID=24424391
|Title=Effects of ZNF804A on auditory P300 response in schizophrenia
|OA=1
}}

{{PMID Auto
|PMID=24462263
|Title=Allelic imbalance associated with the schizophrenia risk SNP rs1344706 indicates a cis-acting variant in ZNF804A
}}

{{PMID Auto
|PMID=22005930
|Title=Genome-wide association study of Alzheimer's disease with psychotic symptoms.
|OA=1
}}

{{PMID Auto
|PMID=22775511
|Title=ZNF804A rs1344706 variant and schizophrenia in a Romanian population from Cluj Napoca.
}}

{{PMID Auto
|PMID=22781169
|Title=Evidence for the involvement of ZNF804A in cognitive processes of relevance to reading and spelling.
|OA=1
}}

{{PMID Auto
|PMID=22840435
|Title=An investigation of a genomewide supported psychosis variant in ZNF804A and white matter integrity in the human brain.
|OA=1
}}

{{PMID Auto
|PMID=22871346
|Title=Further evidence for the association of genetic variants of ZNF804A with schizophrenia and a meta-analysis for genome-wide significance variant rs1344706.
}}

{{PMID Auto
|PMID=22887939
|Title=ZNF804A and schizophrenia susceptibility in Asian populations.
}}

{{PMID Auto
|PMID=23147122
|Title=No association of ZNF804A rs1344706 with white matter integrity in schizophrenia: a tract-based spatial statistics study.
}}

{{PMID Auto
|PMID=23295962
|Title=ZNF804A genotype modulates neural activity during working memory for faces.
|OA=1
}}

{{PMID Auto
|PMID=23590871
|Title=Association of rs1344706 in the ZNF804A gene with schizophrenia in a case/control sample from Indonesia.
}}

{{PMID Auto
|PMID=25162540
|Title=Expression of ZNF804A in Human Brain and Alterations in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder: A Novel Transcript Fetally Regulated by the Psychosis Risk Variant rs1344706
}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}