{{Rsnum
|rsid=1346044
|Gene=WRN
|Chromosome=8
|position=31167138
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.1827
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=WRN
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 6.2 | 46.9 | 46.9
| HCB | 0.7 | 16.8 | 82.5
| JPT | 0.0 | 16.8 | 83.2
| YRI | 1.4 | 21.8 | 76.9
| ASW | 7.0 | 24.6 | 68.4
| CHB | 0.7 | 16.8 | 82.5
| CHD | 0.0 | 25.9 | 74.1
| GIH | 9.9 | 37.6 | 52.5
| LWK | 4.5 | 30.9 | 64.5
| MEX | 0.0 | 37.9 | 62.1
| MKK | 7.1 | 38.5 | 54.5
| TSI | 3.0 | 48.5 | 48.5
| HapMapRevision=28
}}{{PMID Auto
|PMID=19282863
|Title=Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension
}}

{{PMID Auto
|PMID=19945966
|Title=Colorectal cancer and polymorphisms in DNA repair genes WRN, RMI1 and BLM
}}

{{PMID Auto
|PMID=16857995
|Title=Risk of non-Hodgkin lymphoma (NHL) in relation to germline variation in DNA repair and related genes.
|OA=1
}}

{{PMID Auto
|PMID=18194558
|Title=A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.
|OA=1
}}

{{PMID Auto
|PMID=18978339
|Title=Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity.
|OA=1
}}

{{GET Evidence
|gene=WRN
|aa_change=Cys1367Arg
|aa_change_short=C1367R
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1346044
|overall_frequency_n=2467
|overall_frequency_d=10758
|overall_frequency=0.229318
|n_genomes=17
|n_genomes_annotated=0
|n_haplomes=19
|n_articles=0
|n_articles_annotated=0
|gene_in_genetests=Y
|genetests_reviewed=Y
|nblosum100=8
|autoscore=2
|n_web_uneval=10
}}

{{PMID Auto
|PMID=23334603
|Title=Polymorphisms of the WRN gene and DNA damage of peripheral lymphocytes in age-related cataract in a Han Chinese population.
}}

{{PMID Auto
|PMID=24944800
|Title=WRN Cys1367Arg polymorphism is not associated with skull base chordoma
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}