{{Rsnum
|rsid=135745
|Chromosome=22
|position=38287631
|Orientation=plus
|GMAF=0.4132
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;G)
| geno3=(G;G)
| CEU | 29.2 | 54.0 | 16.8
| HCB | 2.2 | 26.3 | 71.5
| JPT | 7.1 | 41.6 | 51.3
| YRI | 13.6 | 47.6 | 38.8
| ASW | 15.8 | 47.4 | 36.8
| CHB | 2.2 | 26.3 | 71.5
| CHD | 0.9 | 28.4 | 70.6
| GIH | 25.7 | 48.5 | 25.7
| LWK | 22.0 | 40.4 | 37.6
| MEX | 34.5 | 39.7 | 25.9
| MKK | 14.1 | 48.7 | 37.2
| TSI | 21.6 | 54.9 | 23.5
| HapMapRevision=28
}}This SNP, located in the 3' UTR of the [[CSNK1E]] gene, has been associated with sensitivity to the acute effects of [[amphetamine|d-amphetamine]]. Sensitivity to psychoactive drugs has been associated with potential to develop [[drug abuse]]. The more sensitive allele is [[rs135745(C)]]. {{PMID|16237383}}

However, in a separate study, this SNP did not affect susceptibility to [[methamphetamine]] dependence or psychosis, at least in a Japanese population.{{PMID|18991847}} 

Note: orientation relative to dbSNP needs to be confirmed/checked.

{{PMID Auto
|PMID=18518925
|Title=Genetic susceptibility to heroin addiction: a candidate gene association study.
|OA=1
}}

{{PMID Auto
|PMID=19050854
|Title=A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine.
|OA=1
}}

{{PMID Auto
|PMID=20174623
|Title=Systematic analysis of circadian genes in a population-based sample reveals association of TIMELESS with depression and sleep disturbance.
|OA=1
}}

{{PMID Auto
|PMID=22367616
|Title=Association between a casein kinase 1 epsilon gene polymorphism and schizophrenia in a Chinese Han population.
}}

{{PMID Auto
|PMID=22113361
|Title=No association of a casein kinase 1epsilon (CK1epsilon) gene polymorphism with personality traits in healthy Chinese-Han subjects.
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}