{{Rsnum
|rsid=1360780
|Gene=FKBP5
|Chromosome=6
|position=35639794
|Orientation=plus
|GMAF=0.2994
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=FKBP5
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 52.7 | 41.1 | 6.2
| HCB | 56.3 | 39.3 | 4.4
| JPT | 61.6 | 34.8 | 3.6
| YRI | 30.6 | 49.0 | 20.4
| ASW | 27.3 | 54.5 | 18.2
| CHB | 56.3 | 39.3 | 4.4
| CHD | 58.7 | 31.2 | 10.1
| GIH | 40.6 | 45.5 | 13.9
| LWK | 46.4 | 39.1 | 14.5
| MEX | 58.6 | 39.7 | 1.7
| MKK | 36.5 | 48.1 | 15.4
| TSI | 44.1 | 41.2 | 14.7
| HapMapRevision=28
}}
In Caucasian non-Hispanics, the [[rs1360780]](T) allele is associated with increased risk for [[depression]], with an odds ratio of 1.39 (CI: 1.14-1.70, p=0.046).{{PMID|18191112|OA=1
}}

This same SNP, which is in the [[FKBP5]] gene, may influence how patients respond to [[antidepressants]] including [[citalopram]]. [[rs1360780]](T;T) homozgyotes tend to report more depressive episodes, but they also respond better to treatment with [[antidepressants]].{{PMID|15565110}}

{{PMID|18349090|OA=1
}} [[rs9296158]] [[rs3800373]] [[rs1360780]] [[rs9470080]] linked with the severity of child abuse to predict level of adult [[PTSD]] symptoms after correcting for multiple testing.

{{omim
|id=602623
|desc=FK506-BINDING PROTEIN 5; FKBP5
|rsnum=1360780
}}
{{PMID Auto
|PMID=19924111
|Title=Polymorphisms in GRIK4, HTR2A, and FKBP5 Show Interactive Effects in Predicting Remission to Antidepressant Treatment
|OA=1
}}

{{PharmGKB
|RSID=rs1360780
|Name_s=
|Gene_s=FKBP5
|Feature=
|Evidence=PubMed ID:15565111; PubMed ID:18349090; PubMed ID:18597649
|Annotation=This variant is associated with higher chance of response to anti-depressant drugs.
|Drugs=desipramine; fluoxetine; mirtazapine; venlafaxine
|Drug Classes=
|Diseases=Depression
|Curation Level=Curated
|PharmGKB Accession ID=PA162168154
}}

{{PMID Auto
|PMID=20090668
|Title=Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide
|OA=1
}}
{{PMID Auto
|PMID=19233472
|Title=Long-range linkage on chromosome 6p of VEGF, FKBP5, HLA and TNF alleles associated with transplant rejection
}}

{{PMID Auto
|PMID=20008943
|Title=Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study
|OA=1
}}

{{PMID Auto
|PMID=20393453
|Title=Interaction of FKBP5 with Childhood Adversity on Risk for Post-Traumatic Stress Disorder
|OA=1
}}
{{PMID Auto
|PMID=20547006
|Title=FKBP5 and resistant attachment predict cortisol reactivity in infants: Gene-environment interaction
}}
{{PMID Auto
|PMID=20709156
|Title=Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders
}}

{{omim
|id=602623
|rsnum=1360780
|variant=0001
}}

{{PMID Auto
|PMID=21654733
|Title=Moderation of Adult Depression by a Polymorphism in the FKBP5 Gene and Childhood Physical Abuse in the General Population
|OA=1
}}

{{PMID Auto
|PMID=22134958
|Title=Relationship between FKBP5 polymorphisms and depression symptoms among kidney transplant recipients
}}

{{PMID Auto
|PMID=21788965
|Title=Glucocorticoid resistance in Crohn's disease and ulcerative colitis: an association study investigating GR and FKBP5 gene polymorphisms.
}}

{{PMID Auto
|PMID=22825419
|Title=FK506-binding protein 51 (FKBP5) gene polymorphism is not associated with glucocorticoid therapy outcome in patients with idiopathic thrombocytopenic purpura
}}

{{PMID Auto
|PMID=15637659
|Title=Linkage disequilibrium patterns and tagSNP transferability among European populations.
|OA=1
}}

{{PMID Auto
|PMID=17081296
|Title=Is FKBP5 a genetic marker of affective psychosis? A case control study and analysis of disease related traits.
|OA=1
}}

{{PMID Auto
|PMID=18702710
|Title=Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls.
}}

{{PMID Auto
|PMID=18803430
|Title=Pharmacogenetics of major depression: insights from level 1 of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) trial.
|OA=1
}}

{{PMID Auto
|PMID=19199039
|Title=Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder.
|OA=1
}}

{{PMID Auto
|PMID=19455174
|Title=Psychobiology and molecular genetics of resilience.
|OA=1
}}

{{PMID Auto
|PMID=19676097
|Title=FKBP5 polymorphisms and antidepressant response in geriatric depression.
|OA=1
}}

{{PMID Auto
|PMID=20226536
|Title=Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort.
}}

{{PMID Auto
|PMID=20726698
|Title=Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals.
|OA=1
}}

{{PMID Auto
|PMID=20849924
|Title=Association study between a functional polymorphism of FK506-binding protein 51 (FKBP5) gene and personality traits in healthy subjects.
}}

{{PMID Auto
|PMID=21112363
|Title=Association of FKBP5 gene haplotypes with completed suicide in the Japanese population.
}}

{{PMID Auto
|PMID=21172166
|Title=Pharmacogenetics of antidepressant response.
|OA=1
}}

{{PMID Auto
|PMID=21316860
|Title=Genetics of cortisol secretion and depressive symptoms: a candidate gene and genome wide association approach.
|OA=1
}}

{{PMID Auto
|PMID=21449676
|Title=Clinical and genetic correlates of suicidal ideation during antidepressant treatment in a depressed outpatient sample.
}}

{{PMID Auto
|PMID=22213790
|Title=Interaction between FKBP5 and childhood trauma and risk of aggressive behavior.
|OA=1
}}

{{PMID Auto
|PMID=22979952
|Title=FKBP5 AND EMOTIONAL NEGLECT INTERACT TO PREDICT INDIVIDUAL DIFFERENCES IN AMYGDALA REACTIVITY
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1360780
|overall_frequency_n=82
|overall_frequency_d=128
|overall_frequency=0.640625
|n_genomes=51
|n_genomes_annotated=0
|n_haplomes=78
|n_articles=0
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto
|PMID=22781842
|Title=Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior
|OA=1
}}

{{PMID Auto
|PMID=24253961
|Title=FKBP5 Genotype and Structural Integrity of the Posterior Cingulum
}}

{{PMID Auto
|PMID=22459275
|Title=FKBP5 polymorphisms as vulnerability to anxiety and depression in patients with advanced gastric cancer: a controlled and prospective study.
}}

{{PMID Auto
|PMID=23733030
|Title=Pharmacogenetics in major depression: a comprehensive meta-analysis.
}}

{{PMID Auto
|PMID=24766650
|Title=Drug Addiction and Stress-Response Genetic Variability: Association Study in African Americans
}}

{{PMID Auto
|PMID=24845178
|Title=Stress-related genes and heroin addiction: A role for a functional FKBP5 haplotype
}}

{{PMID Auto
|PMID=24856550
|Title=FKBP5 polymorphism is associated with major depression but not with bipolar disorder
}}

{{PMID Auto
|PMID=25088286
|Title=Association between the common functional FKBP5 variant (rs1360780) and brain structure in a non-clinical population
}}

{{PMID Auto
|PMID=25115650
|Title=Placental FKBP5 Genetic and Epigenetic Variation Is Associated with Infant Neurobehavioral Outcomes in the RICHS Cohort
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}