{{Rsnum
|rsid=1364043
|Chromosome=5
|position=63955024
|Orientation=plus
|GMAF=0.3154
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(G;G)
| geno2=(G;T)
| geno3=(T;T)
| CEU | 3.5 | 36.3 | 60.2
| HCB | 35.8 | 47.4 | 16.8
| JPT | 42.5 | 47.8 | 9.7
| YRI | 4.1 | 33.3 | 62.6
| ASW | 1.8 | 21.1 | 77.2
| CHB | 35.8 | 47.4 | 16.8
| CHD | 34.9 | 48.6 | 16.5
| GIH | 15.8 | 38.6 | 45.5
| LWK | 4.5 | 24.5 | 70.9
| MEX | 3.4 | 37.9 | 58.6
| MKK | 0.0 | 23.7 | 76.3
| TSI | 1.0 | 33.3 | 65.7
| HapMapRevision=28
}}
{{PMID Auto
|PMID=19326813
|Title=A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers
}}

{{PharmGKB
|RSID=rs1364043
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18484082
|Annotation=A study, investigating the response of SSRI in 137 Japanese major depression subjects, observed a significant association of better response to antidepressant in rs10042486 (P < 0.0001), rs6295 (P < 0.0001) and rs1364043 (P = 0.018) genotype carriers (minor allele homozygotes), independently from clinical variables. The rs6295 variant has been found to affect the expression and function of HTR1A. rs6295 is in strong linkage disequilibrium with other polymorphisms of HTR1A.
|Drugs=fluvoxamine; paroxetine
|Drug Classes=
|Diseases=Depression
|Curation Level=Curated
|PharmGKB Accession ID=PA161749004
}}

{{PMID|18163385|OA=1
}} Association study between the serotonin 1A receptor (HTR1A) gene and neuroticism, major depression, and anxiety disorders.

{{PMID|19829169|OA=1
}} SSRI response in depression may be influenced by SNPs in HTR1B and HTR1A.

{{PMID|21172166|OA=1
}} Pharmacogenetics of antidepressant response.

{{PMID|22064163}} Sertraline (Zoloft) response in major depressive disorder is not associated with three 5-HT1A receptor gene polymorphisms (rs6295, rs10042486, or rs1364043) in Chinese-Han patients.

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1364043
|overall_frequency_n=32
|overall_frequency_d=128
|overall_frequency=0.25
|n_genomes=26
|n_genomes_annotated=0
|n_haplomes=28
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}