{{Rsnum
|rsid=1376251
|Gene=PRH1
|Chromosome=12
|position=11138852
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.3981
|Gene_s=PRH1,PRR4,TAS2R50
|Assembly=GRCh37.p2
|GenomeBuild=37.2
|dbSNPBuild=134
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 42.2 | 45.3 | 12.5
| HCB | 11.1 | 35.6 | 53.3
| JPT | 2.3 | 36.4 | 61.4
| YRI | 92.1 | 7.9 | 0.0
| ASW | 0.0 | 0.0 | 0.0
| CHB | 11.1 | 35.6 | 53.3
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}

rs1376251 increases susceptibility to Myocardial Infarction 1.23 times for heterozygotes (CT) and 1.58 times for homozygotes (CC) {{PMID|16175505|OA=1
}}

An independent study of 3657 patients with myocardial infarction (885 women and 2772 men) and 1211 control individuals (598 women and 613 men) did not observe any correlation to this SNP.{{PMID|19709766}}

{{PMID Auto
|PMID=22192511
|Title=KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly
}}

{{PMID Auto
|PMID=22856164
|Title=[Evaluation of association between 9 genetic polymorphism and myocardial infarction in the Siberian population]
}}

{{PMID Auto
|PMID=18599554
|Title=Replication study of 10 genetic polymorphisms associated with coronary heart disease in a specific high-risk population with familial hypercholesterolemia.
|OA=1
}}

{{PMID Auto
|PMID=19092995
|Title=Bitter taste receptors influence glucose homeostasis.
|OA=1
}}

{{PMID Auto
|PMID=19924713
|Title=Use of longitudinal data in genetic studies in the genome-wide association studies era: summary of Group 14.
|OA=1
}}

{{PMID Auto
|PMID=20017983
|Title=Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort.
|OA=1
}}

{{GET Evidence
|gene=TAS2R50
|aa_change=Cys203Tyr
|aa_change_short=C203Y
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1376251
|overall_frequency_n=2711
|overall_frequency_d=10758
|overall_frequency=0.251999
|n_genomes=23
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=0
|n_articles_annotated=0
|nblosum100=6
|autoscore=0
|webscore=N
}}

{{PMID Auto
|PMID=24083639
|Title=Variations in Bitter-Taste Receptor Genes, Dietary Intake, and Colorectal Adenoma Risk
}}

{{on chip | 23andMe v2}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}