{{Rsnum
|rsid=138326449
|Chromosome=11
|Orientation=plus
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene=APOC3
|position=116830638
|Gene_s=APOC3
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
}}[[rs138326449]], also known as IVS2+1G>A, is a rare variant in the apolipoprotein C3 [[APOC3]] gene.

As reported in two large studies published in 2014, [[rs138326449]] is one of several loss of function mutations in the [[APOC3]] gene associated with a >40% lower average triglyceride level in individuals carrying one [[rs138326449]](A) allele and a corresponding decrease in [[coronary artery disease]].{{PMID|24941081}}{{PMID|24941082}}
{{PMID Auto
|PMID=25225788
|Title=A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans
}}