{{Rsnum
|rsid=1385699
|Gene=EDA2R
|Chromosome=X
|position=66605144
|Orientation=plus
|ReferenceAllele=G
|MissenseAllele=A
|GMAF=0.3102
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=EDA2R
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 15.4 | 13.8 | 70.8
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 100.0 | 0.0 | 0.0
| ASW | 72.7 | 20.0 | 7.3
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 8.2 | 3.1 | 88.7
| LWK | 95.3 | 2.8 | 1.9
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[rs1385699]], also known as Arg57Lys, is a SNP in the ectodysplasin A2 receptor [[EDAR2]] gene. This gene is located on the X chromosome.

The [[rs1385699]](T) allele, which is the most common in European populations, was found to be associated with [[baldness|androgenetic alopecia]] in a case-control study of 400 males. {{PMID|18385763}}

{{PMID Auto
|PMID=15902657
|Title=Genetic variation in the human androgen receptor gene is the major determinant of common early-onset androgenetic alopecia.
|OA=1
}}

{{PMID Auto
|PMID=16255080
|Title=A haplotype map of the human genome.
|OA=1
}}

{{PMID Auto
|PMID=19737746
|Title=Population differentiation as an indicator of recent positive selection in humans: an empirical evaluation.
|OA=1
}}

{{PMID Auto
|PMID=20352079
|Title=Genomic and geographic distribution of private SNPs and pathways in human populations.
|OA=1
}}

{{GET Evidence
|gene=EDA2R
|aa_change=Arg57Lys
|aa_change_short=R57K
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1385699
|overall_frequency_n=4892
|overall_frequency_d=8761
|overall_frequency=0.558384
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=66
|n_articles=0
|n_articles_annotated=0
|pph2_score=0.047
|nblosum100=-3
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}