{{Rsnum
|rsid=1387153
|Gene=MIR194-2
|Chromosome=11
|position=92940662
|Orientation=plus
|GMAF=0.3466
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 50.0 | 45.5 | 4.5
| HCB | 34.3 | 54.0 | 11.7
| JPT | 31.9 | 46.9 | 21.2
| YRI | 39.5 | 42.2 | 18.4
| ASW | 36.8 | 50.9 | 12.3
| CHB | 34.3 | 54.0 | 11.7
| CHD | 26.9 | 46.3 | 26.9
| GIH | 39.6 | 44.6 | 15.8
| LWK | 44.5 | 40.9 | 14.5
| MEX | 55.2 | 36.2 | 8.6
| MKK | 53.2 | 39.1 | 7.7
| TSI | 52.9 | 39.2 | 7.8
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19060909
|Trait=Fasting plasma glucose
|Title=A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
|RiskAllele=T
|Pval=2E-36
|OR=0.07
|ORtxt=[0.05-0.08] mmol/l increase
}}

{{PMID Auto
|PMID=19651812
|Title=Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type-2 diabetes amongst Indian Asians and European whites
|OA=1
}}

{{PharmGKB
|RSID=rs1387153
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19060909; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk. (Initial Sample Size: 2,151 individuals; Replication Sample Size: 6,332 cases, 9,132 controls); (Region: 11q21; Reported Gene(s): MTNR1B; Risk Allele: rs1387153-T); (p-value= 2E-36).This variant is associated with Fasting plasma glucose.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740233
}}

{{PMID Auto
|PMID=20536959
|Title=Two susceptible diabetogenic variants near/in MTNR1B are associated with fasting plasma glucose in a Han Chinese cohort
}}
{{PMID Auto GWAS
|PMID=20581827
|Trait=Type 2 diabetes
|Title=Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
|RiskAllele=T
|Pval=8E-15
|OR=1.09
|ORtxt=[1.06-1.11]
|OA=1
}}
{{PMID Auto
|PMID=20858683
|Title=Common variants at ten genomic loci influence hemoglobin A1C levels via glycemic and non-glycemic pathways
|OA=1
}}

{{omim
|id=613233
|rsnum=1387153
}}

{{PMID Auto GWAS
|PMID=21386085
|Trait=None
|Title=A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium
|RiskAllele=C
|Pval=2E-9
|OR=0.2100
|ORtxt=[0.15-0.27] unit decrease
|OA=1
}}

{{PMID Auto
|PMID=21658282
|Title=Melatonin Receptor 1 B Polymorphisms associated with the risk of Gestational Diabetes Mellitus
|OA=1
}}

{{PMID Auto
|PMID=22450346
|Title=The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population
}}

{{PMID Auto
|PMID=22768333
|Title=Association of Genetic Variants of Melatonin Receptor 1B with Gestational Plasma Glucose Level and Risk of Glucose Intolerance in Pregnant Chinese Women
|OA=1
}}

{{PMID Auto
|PMID=19060907
|Title=Variants in MTNR1B influence fasting glucose levels.
|OA=1
}}

{{PMID Auto
|PMID=19324940
|Title=G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release: studies involving 19,605 Europeans.
|OA=1
}}

{{PMID Auto
|PMID=19937311
|Title=Common variants at the GCK, GCKR, G6PC2-ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations.
}}

{{PMID Auto
|PMID=20628598
|Title=Common polymorphisms in MTNR1B, G6PC2 and GCK are associated with increased fasting plasma glucose and impaired beta-cell function in Chinese subjects.
|OA=1
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
|PMID=21445555
|Title=Association study of type 2 diabetes genetic susceptibility variants and risk of pancreatic cancer: an analysis of PanScan-I data.
}}

{{PMID Auto
|PMID=21558052
|Title=A low frequency variant within the GWAS locus of MTNR1B affects fasting glucose concentrations: Genetic risk is modulated by obesity.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1387153
|overall_frequency_n=40
|overall_frequency_d=128
|overall_frequency=0.3125
|n_genomes=30
|n_genomes_annotated=0
|n_haplomes=35
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23690305
|Title=Genetic variants and the risk of gestational diabetes mellitus: a systematic review
}}

{{PMID Auto
|PMID=23560644
|Title=Polymorphisms in genes involved in the free-radical process in patients with sudden sensorineural hearing loss and Meniere's disease.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}