{{Rsnum
|rsid=1393350
|Gene=TYR
|Chromosome=11
|position=89277878
|Orientation=plus
|GMAF=0.1079
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=TYR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 8.0 | 29.2 | 62.8
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 1.8 | 7.0 | 91.2
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.9 | 99.1
| GIH | 1.0 | 18.8 | 80.2
| LWK | 0.0 | 0.0 | 0.0
| MEX | 1.7 | 27.6 | 70.7
| MKK | 0.0 | 2.6 | 97.4
| TSI | 3.9 | 42.2 | 53.9
| HapMapRevision=28
}}[http://blog.23andme.com/2009/07/06/snpwatch-genetic-variants-near-tumor-suppressor-genes-may-increase-risk-for-brain-and-skin-cancer/ 23andMe blog] [[rs1393350]]	A	1.29	[[Melanoma]]
{{Report GE
|PubMed=17952075
|Source=journal
|AffyProbeset=SNP_A-8317938
|AffyOrientation=same
|AlleleA=A
|AlleleB=G
|onGW5=0
|rsid=1393350
|ancestral=
|RiskPopulation=Caucasian
|RiskAllele=A
|CaseFreq=
|ControlFreq=
|OddsRatioHet=
|OddsRatioHom=
|OddsRatioAll=1.52
|Disease=Blue rather than green eyes
|DiseaseSymbol=EC-BG
}}

rs1393350 increases susceptibility to Blond rather than brown hair 1.29 times for carriers of the A allele {{PMID|17952075}}

rs1393350 increases susceptibility to Blue rather than green eyes 1.52 times for carriers of the A allele {{PMID|17952075}}

rs1393350 increases susceptibility to Skin sensitivity to sun 1.26 times for carriers of the A allele {{PMID|17952075}}

{{PMID Auto GWAS
|PMID=19340012
|Trait=Tanning
|Title=Genome-Wide Association Study of Tanning Phenotype in a Population of European Ancestry
|RiskAllele=A
|Pval=2E-13
|OA=1
}}

{{omim
|desc=SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 3; SHEP3
|id=601800
|rsnum=1393350
}}

{{omim
|desc=TYROSINASE; TYR
|id=606933
|rsnum=1393350
}}
{{PMID Auto GWAS
|PMID=19578364
|Trait=Melanoma
|Title=Genome-wide association study identifies three loci associated with melanoma risk
|RiskAllele=A
|Pval=2E-14
|OR=1.29
|ORtxt=[1.21-1.38]
|OA=1
}}

{{PMID Auto GWAS
|PMID=20410501
|Trait=Vitiligo
|Title=Variant of TYR and Autoimmunity Susceptibility Loci in Generalized Vitiligo
|RiskAllele=G
|Pval=2E-18
|OR=1.53
|ORtxt=[1.39-1.68]
|OA=1
}}
{{PMID Auto GWAS
|PMID=20585627
|Trait=Eye color
|Title=Web-based, participant-driven studies yield novel genetic associations for common traits
|RiskAllele=A
|Pval=3E-9
|OR=0.28
|ORtxt=[NR] unit decrease
|OA=1
}}

{{omim
|id=155601
|rsnum=1393350
}}

{{omim
|id=613099
|rsnum=1393350
}}

{{PMID Auto GWAS
|PMID=21983787
|Trait=None
|Title=Genome-wide association study identifies three new melanoma susceptibility loci.
|RiskAllele=A
|Pval=2E-13
|OR=1.3000
|ORtxt=None
|OA=1
}}

{{PMID|18483556|OA=1
}} A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.

{{PMID|19384953|OA=1
}} Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians.

{{PMID|20463881|OA=1
}} Digital quantification of human eye color highlights genetic association of three new loci.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1393350
|overall_frequency_n=14
|overall_frequency_d=128
|overall_frequency=0.109375
|n_genomes=10
|n_genomes_annotated=0
|n_haplomes=11
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23100201
|Title=A single-nucleotide polymorphism (SNP) multiplex system: the association of five SNPs with human eye and hair color in the Slovenian population and comparison using a Bayesian network and logistic regression model
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}