{{Rsnum
|rsid=140504
|Gene=BCR
|Chromosome=22
|position=23285182
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.2025
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=BCR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 0.9 | 24.8 | 74.3
| HCB | 22.8 | 50.0 | 27.2
| JPT | 23.0 | 48.7 | 28.3
| YRI | 0.0 | 4.1 | 95.9
| ASW | 0.0 | 22.8 | 77.2
| CHB | 22.8 | 50.0 | 27.2
| CHD | 22.9 | 47.7 | 29.4
| GIH | 4.0 | 36.6 | 59.4
| LWK | 0.0 | 7.3 | 92.7
| MEX | 1.8 | 14.0 | 84.2
| MKK | 1.3 | 7.1 | 91.6
| TSI | 2.0 | 14.7 | 83.3
| HapMapRevision=28
}}[[rs140504]], a SNP in the [[BCR]] gene on chromosome 22, has been associated with increased risk for [[bipolar disorder]]. The odds ratio for carriers of the minor allele (G) are reported as 1.45 (CI:1.11 - 1.84, p=0.0054) based on a study of 171 Japanese patients.{{PMID|15866548}}

{{Venter SNP
|rsid=140504
|allele=G
|frequency=0.125
|uid=1103691014305
|type=heterozygous_SNP
|hugo=BCR
|ensembl gene=ENSG00000186716
|ensembl transcript=ENST00000305877
|sift=TOLERATED
|disease=A chromosomal aberration involving BCR is a cause of chronic myeloid leukemia (CML) (MIM:608232). Translocation t(9;22)(q34;q11) with ABL1. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
}}

{{omim
|desc=MAJOR AFFECTIVE DISORDER 1; MAFD1
|id=125480
|rsnum=140504
}}

{{GET Evidence
|gene=BCR
|aa_change=Asn796Ser
|aa_change_short=N796S
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs140504
|overall_frequency_n=9432
|overall_frequency_d=10758
|overall_frequency=0.876743
|n_genomes=53
|n_genomes_annotated=0
|n_haplomes=94
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Illumina Human 1M}}