{{Rsnum
|rsid=140621530
|Chromosome=11
|Orientation=plus
|geno1=(G;G)
|geno2=(G;T)
|geno3=(T;T)
|Gene=APOC3
|position=116830897
|Gene_s=APOC3
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
}}[[rs140621530]], also known as IVS3+1G>T, is a rare variant in the apolipoprotein C3 [[APOC3]] gene.

As reported in a large study published in 2014, it is one of four loss of function mutations in the [[APOC3]] gene associated with a >40% lower average triglyceride level in individuals carrying one [[rs140621530]](T) allele and a corresponding decrease in [[coronary artery disease]].{{PMID|24941081}}