{{Rsnum
|rsid=1408799
|Chromosome=9
|position=12672097
|Orientation=plus
|GMAF=0.3499
|Assembly=GRCh37
|GenomeBuild=37.1
|dbSNPBuild=131
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
}}
{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 47.8 | 43.4 | 8.8
| HCB | 0.0 | 2.9 | 97.1
| JPT | 0.0 | 4.4 | 95.6
| YRI | 4.8 | 25.2 | 70.1
| ASW | 3.5 | 36.8 | 59.6
| CHB | 0.0 | 2.9 | 97.1
| CHD | 0.0 | 1.8 | 98.2
| GIH | 9.9 | 41.6 | 48.5
| LWK | 2.7 | 42.7 | 54.5
| MEX | 12.1 | 51.7 | 36.2
| MKK | 9.6 | 42.3 | 48.1
| TSI | 46.1 | 42.2 | 11.8
| HapMapRevision=28
}}{{GWAS Summary
|SNP=rs1408799
|PubMedID=18488028
|Condition=Blue vs. green eyes
|Gene=TYRP1
|Risk Allele=C
|pValue=6.00E-017
|OR=1.4
|95CI=1.25-1.57
}}

{{PMID Auto
|PMID=19384953
|Title=Genetic variants in pigmentation genes, pigmentary phenotypes, and risk of skin cancer in Caucasians
|OA=1
}}

{{omim
|desc=MELANOMA, CUTANEOUS MALIGNANT; CMM
|id=155600
|rsnum=1408799
}}

{{omim
|desc=SKIN/HAIR/EYE PIGMENTATION, VARIATION IN, 11; SHEP11
|id=612271
|rsnum=1408799
}}

{{omim
|desc=TYROSINASE-RELATED PROTEIN 1; TYRP1
|id=115501
|rsnum=1408799
}}

{{PharmGKB
|RSID=rs1408799
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:18488028; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS Results: Two newly identified genetic determinants of pigmentation in Europeans (Initial Sample Size: 5,130 individuals; Replication Sample Size: 3,330 individuals; Risk/trait Allele: rs1408799-C). This variant is associated with Blue vs. green eyes.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA162356584
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1408799
|overall_frequency_n=55
|overall_frequency_d=126
|overall_frequency=0.436508
|n_genomes=31
|n_genomes_annotated=0
|n_haplomes=42
|n_articles=0
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23548203
  |Trait=Eye color
  |Title=Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.
  |RiskAllele=C
  |Pval=5E-7
  |OR=.27
  |ORtxt=[0.17-0.37] unit decrease
  }}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}