{{Rsnum
|rsid=1410996
|Gene=CFH
|Chromosome=1
|position=196727803
|Orientation=minus
|GMAF=0.461
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=CFH
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 38.5 | 41.5 | 20.0
| HCB | 35.6 | 42.2 | 22.2
| JPT | 34.1 | 52.3 | 13.6
| YRI | 9.5 | 49.2 | 41.3
| ASW | 0.0 | 0.0 | 0.0
| CHB | 35.6 | 42.2 | 22.2
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}[[age related macular degeneration]] {{PMID|16936733|OA=1
}}

{{omim
|id=134370
|desc=COMPLEMENT FACTOR H; CFH
|rsnum=1410996
}}
{{PMID Auto
|PMID=19850835
|Title=The noncoding variant in complement factor H gene increases risk of exudative age-related macular degeneration in a Chinese population
}}

{{PMID Auto
|PMID=20132989
|Title=Phenotype and Genotype Characteristics of Age-related Macular Degeneration in a Japanese Population
}}

{{PMID Auto GWAS
|PMID=20385826
|Trait=Age-related macular degeneration
|Title=Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
|RiskAllele=
|Pval=2E-111
|OR=None
|ORtxt=None
|OA=1
}}
{{PMID Auto
|PMID=20678803
|Title=Complement Factor H and High-Temperature Requirement A-1 Genotypes and Treatment Response of Age-related Macular Degeneration
}}

{{omim
|desc=COMPLEMENT FACTOR H-RELATED 1; CFHR1
|id=134371
|rsnum=1410996
}}

{{omim
|desc=COMPLEMENT FACTOR H-RELATED 3; CFHR3
|id=605336
|rsnum=1410996
}}
{{PMID Auto
|PMID=21139980
|Title=Associations of smoking, body mass index, dietary lutein, and the LIPC gene variant rs10468017 with advanced age-related macular degeneration
|OA=1
}}

{{omim
|id=134370
|rsnum=1410996
|variant=0016
}}

{{omim
|id=610698
|rsnum=1410996
}}

{{PMID Auto
|PMID=22019782
|Title=A rare penetrant mutation in CFH confers high risk of age-related macular degeneration
|OA=1
}}

{{PMID Auto
|PMID=17327825
|Title=An update on the genetics of age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=17917691
|Title=Genetic markers and biomarkers for age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=17962488
|Title=Coding and noncoding variants in the CFH gene and cigarette smoking influence the risk of age-related macular degeneration in a Japanese population.
}}

{{PMID Auto
|PMID=18043728
|Title=Haplotypes in the complement factor H (CFH) gene: associations with drusen and advanced age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=18081690
|Title=Translational mini-review series on complement factor H: genetics and disease associations of human complement factor H.
|OA=1
}}

{{PMID Auto
|PMID=19117936
|Title=Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables.
|OA=1
}}

{{PMID Auto
|PMID=19187590
|Title=Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population.
}}

{{PMID Auto
|PMID=19187823
|Title=Coding variant I62V in the complement factor H gene is strongly associated with polypoidal choroidal vasculopathy.
}}

{{PMID Auto
|PMID=19259132
|Title=Multilocus analysis of age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=19661236
|Title=Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes.
|OA=1
}}

{{PMID Auto
|PMID=19861685
|Title=Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome.
|OA=1
}}

{{PMID Auto
|PMID=20157618
|Title=Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort.
|OA=1
}}

{{PMID Auto
|PMID=20378180
|Title=Three major loci involved in age-related macular degeneration are also associated with polypoidal choroidal vasculopathy.
|OA=1
}}

{{PMID Auto
|PMID=21665990
|Title=Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|OA=1
}}

{{PMID Auto
|PMID=21906714
|Title=Evaluation of new and established age-related macular degeneration susceptibility genes in the Women's Health Initiative Sight Exam (WHI-SE) Study.
}}

{{PMID Auto
|PMID=22618592
|Title=Association of genetic polymorphisms and age-related macular degeneration in chinese population.
}}

{{PMID Auto
|PMID=23534868
|Title=CFH (rs1410996), HTRA1 (rs112000638) and ARMS2 (rs10490923) Gene Polymorphisms are Associated with AMD Risk in Spanish Patients
}}

{{PMID Auto GWAS
  |PMID=23381943
  |Trait=End-stage coagulation
  |Title=Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
  |RiskAllele=G
  |Pval=1E-9
  |OR=.20
  |ORtxt=[0.14-0.27] unit increase
  |OA=1
}}

{{PMID Auto
|PMID=23233260
|Title=Association between polymorphisms of complement pathway genes and age-related macular degeneration in a Chinese population.
|OA=1
}}

{{PMID Auto
|PMID=23414945
|Title=Influence of CFH, HTRA1 and ARMS2 haplotype polymorphisms in the development of age-related macular disease
}}

{{PMID Auto
|PMID=24865190
|Title=Association of Specific Genetic Polymorphisms with Age-related Macular Degeneration in a Northern Chinese Population
}}

{{ClinVar
|ALT=A
|CHROM=1
|CLNACC=RCV000018024.1
|CLNALLE=0
|CLNDBN=Age-related macular degeneration 4
|CLNDSDB=MedGen:OMIM
|CLNDSDBID=C1853147:610698
|CLNHGVS=NC_000001.11:g.196727803G\x3d
|CLNORIGIN=1
|CLNSIG=255
|CLNSRC=OMIM Allelic Variant
|CLNSRCID=134370.0016
|Disease=Age-related macular degeneration 4
|FwdALT=T
|FwdREF=C
|GENEINFO=CFH:3075
|GENE_ID=3075
|GENE_NAME=CFH
|REF=G
|RSPOS=196727803
|Reversed=1
|SAO=0
|SSR=0
|Tags=RV;PM;PMC;SLO;INT;OTH;ASP;VLD;G5A;G5;HD;GNO;KGPhase1;KGPilot123;KGPROD;OTHERKG;PH3;MTP;OM
|VC=SNV
|VP=0x05016808001517051f030100
|WGT=1
|dbSNPBuildID=88
|rsid=1410996
}}
{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}