{{Rsnum
|rsid=1420101
|Gene=IL1RL1
|Chromosome=2
|position=102341256
|Orientation=minus
|GMAF=0.3714
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=IL1RL1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 13.3 | 43.4 | 43.4
| HCB | 16.5 | 45.9 | 37.6
| JPT | 20.7 | 50.5 | 28.8
| YRI | 11.0 | 42.5 | 46.6
| ASW | 14.0 | 57.9 | 28.1
| CHB | 16.5 | 45.9 | 37.6
| CHD | 13.1 | 50.5 | 36.4
| GIH | 12.9 | 45.5 | 41.6
| LWK | 19.4 | 50.0 | 30.6
| MEX | 10.5 | 33.3 | 56.1
| MKK | 21.9 | 44.5 | 33.5
| TSI | 16.8 | 49.5 | 33.7
| HapMapRevision=28
}}
[http://www.koreatimes.co.kr/www/news/art/2009/02/147_39603.html news] linked to [[asthma]]

{{PMID Auto GWAS
|PMID=19198610
|Trait=Plasma eosinophil count
|Title=Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
|RiskAllele=A
|Pval=5E-14
|OR=6.40
|ORtxt=[4.7-8.1] % standard unit increase
}}

{{PharmGKB
|RSID=rs1420101
|Name_s=
|Gene_s=IL1RL1
|Feature=
|Evidence=PubMed ID:19198610; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. (Initial Sample Size: 9,392 individuals; Replication Sample Size: 12,118 individuals); (Region: 2q12.1; Reported Gene(s): IL1RL1; Risk Allele: rs1420101-A); (p-value= 0.00000000000005).This variant is associated with Plasma eosinophil count.
|Drugs=
|Drug Classes=
|Diseases=
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164739958
}}

{{PharmGKB
|RSID=rs1420101
|Name_s=
|Gene_s=IL1RL1
|Feature=
|Evidence=PubMed ID:19198610
|Annotation=The SNP at IL1RL1 was associated with asthma (P = 5.5 x 10(-12)) in a collection of ten different populations (7,996 cases and 44,890 controls).
|Drugs=
|Drug Classes=
|Diseases=Asthma
|Curation Level=Curated
|PharmGKB Accession ID=PA163522165
}}

{{PMID Auto
|PMID=22574108
|Title=IL1RL1 Gene Variants and Nasopharyngeal IL1RL-a Levels Are Associated with Severe RSV Bronchiolitis: A Multicenter Cohort Study
|OA=1
}}

{{PMID|19852851|OA=1
}} Asthma and genes encoding components of the vitamin D pathway.

{{PMID|19860791}} Genetic evidence for a role of IL33 in nasal polyposis.

{{PMID|21281963}} Interleukin-1 receptor-like 1 polymorphisms are associated with serum IL1RL1-a, eosinophils, and asthma in childhood.

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1420101
|overall_frequency_n=54
|overall_frequency_d=128
|overall_frequency=0.421875
|n_genomes=37
|n_genomes_annotated=0
|n_haplomes=45
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23028483
|Title=Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.
|OA=1
}}

{{PMID Auto
|PMID=23328882
|Title=Meta-analyses of four eosinophil related gene variants in coronary heart disease.
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}