{{Rsnum
|rsid=1424233
|Chromosome=16
|position=79648854
|Orientation=minus
|GMAF=0.404
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 30.1 | 51.3 | 18.6
| HCB | 47.4 | 43.8 | 8.8
| JPT | 56.6 | 36.3 | 7.1
| YRI | 44.9 | 42.2 | 12.9
| ASW | 50.9 | 36.8 | 12.3
| CHB | 47.4 | 43.8 | 8.8
| CHD | 42.2 | 47.7 | 10.1
| GIH | 47.5 | 41.6 | 10.9
| LWK | 44.5 | 42.7 | 12.7
| MEX | 55.2 | 37.9 | 6.9
| MKK | 40.4 | 49.4 | 10.3
| TSI | 28.4 | 53.9 | 17.6
| HapMapRevision=28
}}
{{PMID Auto GWAS
|PMID=19151714
|Trait=Obesity
|Title=Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
|RiskAllele=A
|Pval=4E-13
|OR=1.12
|ORtxt=[1.00-1.24]
}}

{{omim
|desc=BODY MASS INDEX; BMI
|id=606641
|rsnum=1424233
}}

{{PharmGKB
|RSID=rs1424233
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19174833
|Annotation=The analyses of genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls found an association of this variant (rs1424233) near MAF for risk of pooled childhood and adult severe obesity.
|Drugs=
|Drug Classes=
|Diseases=Obesity
|Curation Level=Curated
|PharmGKB Accession ID=PA162565812
}}

{{PharmGKB
|RSID=rs1424233
|Name_s=
|Gene_s=-
|Feature=
|Evidence=PubMed ID:19151714; Web Resource:http://www.genome.gov/gwastudies/
|Annotation=GWAS results: Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. (Initial Sample Size: 695 obese adults, 685 obese children, 731 lean adults, 685 lean children; Replication Sample Size: 1,171 obese adults, 896 obese children, 1,114 lean adults, 1,297 lean children, 4,417 adults, 5,291 children); (Region: 16q23.2; Reported Gene(s): MAF; Risk Allele: rs1424233-A); (p-value= 0.0000000000004).This variant is associated with Obesity.
|Drugs=
|Drug Classes=
|Diseases=Obesity
|Curation Level=Non-Curated
|PharmGKB Accession ID=PA164740069
}}

{{PMID Auto
|PMID=21796141
|Title=Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area
}}

{{PMID Auto
|PMID=21912638
|Title=Studies of metabolic phenotypic correlates of 15 obesity associated gene variants
|OA=1
}}

{{PMID Auto
|PMID=19526209
|Title=Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?
|OA=1
}}

{{PMID Auto
|PMID=19553259
|Title=Common body mass index-associated variants confer risk of extreme obesity.
|OA=1
}}

{{PMID Auto
|PMID=20127379
|Title=From monogenic to polygenic obesity: recent advances.
|OA=1
}}

{{PMID Auto
|PMID=20712903
|Title=Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
|OA=1
}}

{{PMID Auto
|PMID=22430306
|Title=Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples.
|OA=1
}}

{{GET Evidence
|impact=pathogenic
|qualified_impact=Insufficiently evaluated pathogenic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1424233
|overall_frequency_n=50
|overall_frequency_d=128
|overall_frequency=0.390625
|n_genomes=32
|n_genomes_annotated=0
|n_haplomes=40
|n_articles=1
|n_articles_annotated=0
|in_gwas=Y
|in_pharmgkb=Y
|autoscore=2
|webscore=N
}}

{{PMID Auto
|PMID=23471855
|Title=The genetics of childhood obesity and interaction with dietary macronutrients.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Illumina Human 1M}}