{{Rsnum
|rsid=1426310
|Gene=DSG1
|Chromosome=18
|position=31318331
|Orientation=plus
|ReferenceAllele=A
|MissenseAllele=G
|GMAF=0.3457
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=DSG1
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 25.7 | 57.5 | 16.8
| HCB | 89.8 | 10.2 | 0.0
| JPT | 85.8 | 14.2 | 0.0
| YRI | 24.5 | 50.3 | 25.2
| ASW | 31.6 | 50.9 | 17.5
| CHB | 89.8 | 10.2 | 0.0
| CHD | 89.0 | 11.0 | 0.0
| GIH | 25.7 | 52.5 | 21.8
| LWK | 45.5 | 42.7 | 11.8
| MEX | 58.6 | 36.2 | 5.2
| MKK | 37.8 | 50.0 | 12.2
| TSI | 27.5 | 47.1 | 25.5
| HapMapRevision=28
}}

{{Venter SNP
|rsid=1426310
|allele=G
|frequency=0.492
|uid=1103645166626
|type=heterozygous_SNP
|hugo=DSG1
|ensembl gene=ENSG00000134760
|ensembl transcript=ENST00000257192
|sift=TOLERATED
|disease=Defects in DSG1 are the cause of keratosis palmoplantaris striata I (PPKS1) (MIM:148700); also known as striate palmoplantar keratoderma I (SPPK1). PPKS1 is an autosomal dominant disease characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger.
}}

{{GET Evidence
|gene=DSG1
|aa_change=Met11Val
|aa_change_short=M11V
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1426310
|overall_frequency_n=5153
|overall_frequency_d=10758
|overall_frequency=0.478992
|n_genomes=29
|n_genomes_annotated=0
|n_haplomes=39
|n_articles=0
|n_articles_annotated=0
|nblosum100=0
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}