{{Rsnum
|rsid=1435252
|Gene=GABBR2
|Chromosome=9
|position=98341309
|Orientation=minus
|GMAF=0.3439
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=GABBR2
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 47.8 | 38.9 | 13.3
| HCB | 29.9 | 44.5 | 25.5
| JPT | 37.2 | 40.7 | 22.1
| YRI | 47.6 | 42.2 | 10.2
| ASW | 33.3 | 54.4 | 12.3
| CHB | 29.9 | 44.5 | 25.5
| CHD | 32.1 | 48.6 | 19.3
| GIH | 48.5 | 44.6 | 6.9
| LWK | 59.6 | 37.6 | 2.8
| MEX | 56.9 | 34.5 | 8.6
| MKK | 66.0 | 30.8 | 3.2
| TSI | 53.9 | 40.2 | 5.9
| HapMapRevision=28
}}

{{PMID|15759211|OA=1
}} Associated with [[nicotine Dependence]] as part of several haplotypes, based on a study of 1,000+ subjects including both African-Americans and European-Americans.

The risk haplotype varies between populations. Among African-Americans, the haplotype C-C-G of [[rs2491397]]-[[rs2184026]]-[[rs3750344]] had a significant positive association with [[nicotine dependence]]. Among European-Americans, for [[rs1435252]]-[[rs3780422]]-[[rs2779562]]-[[rs3750344]], the C-A-C-A haplotype was positively associated with [[nicotine dependence]] while the T-A-T-A haplotype was negatively associated.{{PMID|15759211|OA=1
}}

{{omim
|id=607340
|desc=GAMMA-AMINOBUTYRIC ACID B RECEPTOR 2; GABBR2
|rsnum=1435252
}}

{{omim
|id=607340
|rsnum=1435252
|variant=0002
}}

{{omim
|id=607340
|rsnum=1435252
|variant=0003
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}