{{Rsnum
|rsid=1451371
|Gene=DDC
|Chromosome=7
|position=50485353
|Orientation=plus
|GMAF=0.4096
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Gene_s=DDC
}}{{ population diversity
| geno1=(C;C)
| geno2=(C;T)
| geno3=(T;T)
| CEU | 12.9 | 51.6 | 35.5
| HCB | 25.0 | 36.4 | 38.6
| JPT | 14.3 | 54.8 | 31.0
| YRI | 9.5 | 34.9 | 55.6
| ASW | 0.0 | 0.0 | 0.0
| CHB | 25.0 | 36.4 | 38.6
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 0.0 | 0.0
| LWK | 0.0 | 0.0 | 0.0
| MEX | 0.0 | 0.0 | 0.0
| MKK | 0.0 | 0.0 | 0.0
| TSI | 0.0 | 0.0 | 0.0
| HapMapRevision=28
}}
per OMIM, Ma et al. (2005) {{PMID|15879433}} found two different DDC haplotypes associated with nicotine dependence in African Americans and European Americans (with measures of smoking quantity [SQ], heaviness of [[smoking]] index [HSI], and the Fagerstrom test for ND [FTND])
*in African Americans, [[rs921451]](T), [[rs3735273]](G), [[rs1451371]](T), [[rs2060762]](G), all three measures sig. associated after correction for multiple testing
*in European Americans, [[rs921451]](T), [[rs3735273]](G), [[rs1451371]](T), [[rs3757472]](G), which showed a sig. assoc. w/ the SQ and FTND score

{{PMID Auto
|PMID=19221445
|Title=Tyrosine hydroxylase and DOPA decarboxylase gene variants in personality traits
}}

{{omim
|desc=TOBACCO [[Addiction]], SUSCEPTIBILITY TO
|id=188890
|rsnum=1451371
}}

{{omim
|desc=DOPA DECARBOXYLASE; DDC
|id=107930
|rsnum=1451371
}}

{{PharmGKB
|RSID=rs1451371
|Name_s=
|Gene_s=DDC
|Feature=
|Evidence=PubMed ID:15879433
|Annotation=A study on 2037 smokers and non-smokers from 602 nuclear families of African- or European-American ancestry found first evidence for the involvement of DDC in the susceptibility to nicotine dependence. This variant in the DDC gene is part of two haplotypes, a protective T-G-T-G haplotype for rs921451-rs3735273-rs1451371-rs2060762 in the African-American sample and a high-risk T-G-T-G haplotype for rs921451-rs3735273-rs1451371-rs3757472 in the European-American sample.
|Drugs=nicotine
|Drug Classes=
|Diseases=Tobacco Use Disorder
|Curation Level=Curated
|PharmGKB Accession ID=PA162316616
}}

{{PMID Auto
|PMID=17184203
|Title=DOPA decarboxylase gene is associated with nicotine dependence.
}}

{{PMID Auto
|PMID=17948905
|Title=Dopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behavior.
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1451371
|overall_frequency_n=50
|overall_frequency_d=124
|overall_frequency=0.403226
|n_genomes=36
|n_genomes_annotated=0
|n_haplomes=44
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | HumanOmni1Quad}}