{{Rsnum
|rsid=145518263
|geno1=(C;C)
|geno2=(C;T)
|geno3=(T;T)
|Chromosome=15
|Orientation=plus
|Gene=ADAM10
|position=58665141
|Gene_s=ADAM10
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
}}[[rs145518263]], also known as R181G or Arg181Gly, is a SNP in the ADAM metallopeptidase domain 10 [[ADAM10]] gene. The common allele is [[rs145518263]](T), encoding the Arg.

{{PMID|19608551|OA=1
}} The [[rs145518263]](C) allele was found in 11 of 16 individuals affected by [[Alzheimer's disease]] (average onset age 69.5 years) from seven late-onset AD families. This mutation was also found in at least one unaffected subject implying incomplete [http://www.snpedia.com/index.php/Glossary penetrance].