{{Rsnum
|rsid=1467558
|Gene=CD44
|Chromosome=11
|position=35208126
|Orientation=plus
|ReferenceAllele=T
|MissenseAllele=C
|GMAF=0.08356
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=CD44
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 3.5 | 31.9 | 64.6
| HCB | 0.0 | 0.0 | 100.0
| JPT | 0.0 | 0.0 | 100.0
| YRI | 0.0 | 0.0 | 100.0
| ASW | 0.0 | 5.3 | 94.7
| CHB | 0.0 | 0.0 | 100.0
| CHD | 0.0 | 0.0 | 0.0
| GIH | 0.0 | 10.9 | 89.1
| LWK | 0.0 | 1.8 | 98.2
| MEX | 0.0 | 19.0 | 81.0
| MKK | 0.0 | 5.8 | 94.2
| TSI | 1.0 | 29.4 | 69.6
| HapMapRevision=28
}}{{PMID|19416960|OA=1
}} After taking [[Acetaminophen]] ([[Tylenol]]®), [[rs1467558]](A;G) individuals have higher alanine aminotransferase (ALT) levels, a sign of liver toxicity, than do (G;G) homozygotes. More studies are needed; there was only 1 (A;A) individual, and he didn't show elevated ALT levels; furthermore, the ALT increases were "modest" anyway for (A;G) individuals compared to (G;G). see also: [http://blog.23andme.com/2009/05/08/snpwatch-genetic-variation-in-immune-system-protein-may-mediate-adverse-reactions-to-acetaminophen/ 23andMe blog]

'''Note:''' the orientation of this SNP in SNPedia is as detailed in dbSNP, but in publications (including 23andMe's blog) the orientation is 'flipped', so what's (A;A) in dbSNP is (T;T) as discussed by the 23andMe blog.

{{PMID Auto
|PMID=17903303
|Title=Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study.
|OA=1
}}

{{PMID Auto
|PMID=18194558
|Title=A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.
|OA=1
}}

{{GET Evidence
|gene=CD44
|aa_change=Ile479Thr
|aa_change_short=I479T
|impact=not reviewed
|qualified_impact=Insufficiently evaluated not reviewed
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1467558
|overall_frequency_n=9284
|overall_frequency_d=10758
|overall_frequency=0.862986
|n_genomes=56
|n_genomes_annotated=0
|n_haplomes=103
|n_articles=0
|n_articles_annotated=0
|nblosum100=3
|autoscore=0
|webscore=N
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}