{{Rsnum
|rsid=1470579
|Gene=IGF2BP2
|Chromosome=3
|position=185811292
|Orientation=plus
|GMAF=0.4123
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=IGF2BP2
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 50.4 | 39.8 | 9.7
| HCB | 56.6 | 39.7 | 3.7
| JPT | 45.1 | 45.1 | 9.7
| YRI | 2.1 | 24.7 | 73.3
| ASW | 12.5 | 41.1 | 46.4
| CHB | 56.6 | 39.7 | 3.7
| CHD | 52.3 | 39.4 | 8.3
| GIH | 23.8 | 53.5 | 22.8
| LWK | 2.7 | 22.7 | 74.5
| MEX | 58.6 | 36.2 | 5.2
| MKK | 3.8 | 39.1 | 57.1
| TSI | 58.6 | 30.3 | 11.1
| HapMapRevision=28
}}
{{PMID|18477659}} [[rs1470579]] replicated as significant for type-2 diabetes risk in 1,900 Japanese patients, with odds ratio of 1.18 (CI: 1.07-1.31, p = 8.3 x 10e-4)

{{PMID|18461161|OA=1
}} T2D and normal glucose tolerant (NGT) individuals. (3,295 T2D and 3,595 NGT), strong associations with T2D were found for 
*CDKAL1 (OR([[rs7756992]]) = 1.30[1.19-1.42], P = 2.3x10(-9))
*CDKN2A/2B (OR([[rs10811661]]) = 0.74[0.66-0.82], P = 3.5x10(-8))
*IGFBP2 (OR([[rs1470579]]) = 1.17[1.07-1.27], P = 0.0003) SNPs. 
T2D risk increased strongly when risk alleles, including the previously discovered T2D-associated TCF7L2 [[rs7903146]] SNP, were combined (8.68-fold for the 14% of French individuals carrying 18 to 30 risk alleles with an allelic OR of 1.24)

{{PMID|18430866|OA=1
}} Neither [[rs4402960]] or [[rs1470579]] were found to be associated with [[type-2 diabetes]] in a study of 3,000 French Caucasians.

{{PMID|19033397|OA=1
}} This SNP was confirmed to be associated with [[type-2 diabetes]] in a study of 500+ Japanese patients plus pooled meta-analysis with 6 previous association studies (also of Japanese).

Note: [[rs1470579]] is fairly tightly linked (r2=0.87) with another [[IGF2BP2]] gene SNP also associated with type-2 diabetes, [[rs4402960]]

{{PMID Auto GWAS
|PMID=17463246
|Trait=Type 2 diabetes
|Title=Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
|RiskAllele=C
|Pval=1E-9
|OR=1.17
|ORtxt=[1.11-1.23]
}}

{{PharmGKB
|RSID=rs1470579
|Name_s=
|Gene_s=IGF2BP2
|Feature=
|Evidence=PubMed ID:18461161
|Annotation=This variant has been reported to be moderately associated with type 2 diabetes.
|Drugs=
|Drug Classes=
|Diseases=Diabetes Mellitus, Type 2
|Curation Level=Curated
|PharmGKB Accession ID=PA161749008
}}

{{PMID Auto
|PMID=20523342
|Title=IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population
}}
{{PMID Auto GWAS
|PMID=20581827
|Trait=Type 2 diabetes
|Title=Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
|RiskAllele=C
|Pval=2E-9
|OR=1.14
|ORtxt=[1.09-1.19]
|OA=1
}}

{{PMID Auto GWAS
|PMID=22233651
|Trait=None
|Title=A genome-wide association study of gestational diabetes mellitus in korean women.
|RiskAllele=C
|Pval=2E-7
|OR=1.3320
|ORtxt=None
|OA=1
}}

{{PMID Auto
|PMID=22569928
|Title=Analysis of common type 2 diabetes mellitus genetic risk factors in new-onset diabetes after transplantation in kidney transplant patients medicated with tacrolimus
|OA=1
}}

{{PMID Auto
|PMID=18426861
|Title=Association analysis of type 2 diabetes Loci in type 1 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=18544707
|Title=Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention program.
|OA=1
}}

{{PMID Auto
|PMID=18633108
|Title=Common variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE genes are associated with type 2 diabetes and impaired fasting glucose in a Chinese Han population.
|OA=1
}}

{{PMID Auto
|PMID=19008344
|Title=Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians.
|OA=1
}}

{{PMID Auto
|PMID=19020323
|Title=Genotype score in addition to common risk factors for prediction of type 2 diabetes.
|OA=1
}}

{{PMID Auto
|PMID=19096518
|Title=Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.
|OA=1
}}

{{PMID Auto
|PMID=19956539
|Title=How many genetic variants remain to be discovered?
|OA=1
}}

{{PMID Auto
|PMID=20043853
|Title=Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus.
|OA=1
}}

{{PMID Auto
|PMID=20144327
|Title=A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel.
|OA=1
}}

{{PMID Auto
|PMID=22015911
|Title=Quantitative assessment of the variation in IGF2BP2 gene and type 2 diabetes risk.
}}

{{PMID Auto
|PMID=22245690
|Title=Strong association of common variants in the IGF2BP2 gene with type 2 diabetes in Lebanese Arabs.
}}

{{PMID Auto
|PMID=22377712
|Title=Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography.
}}

{{PMID Auto GWAS
|PMID=22581228
|Trait=None
|Title=A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.
|RiskAllele=
|Pval=6E-7
|OR=None
|ORtxt=None
|OA=1
}}

{{GET Evidence
|impact=pharmacogenetic
|qualified_impact=Insufficiently evaluated pharmacogenetic
|inheritance=unknown
|quality_scores=Array
|dbsnp_id=rs1470579
|overall_frequency_n=54
|overall_frequency_d=122
|overall_frequency=0.442623
|n_genomes=34
|n_genomes_annotated=0
|n_haplomes=48
|n_articles=1
|n_articles_annotated=0
|in_pharmgkb=Y
|autoscore=1
|webscore=N
}}

{{PMID Auto GWAS
  |PMID=23300278
  |Trait=Type 2 diabetes
  |Title=Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India.
  |RiskAllele=C
  |Pval=2E-13
  |OR=1.06
  |ORtxt=[1.04-1.08]
  |OA=1
}}

{{PMID Auto
|PMID=22749234
|Title=Contribution of common variants of ENPP1, IGF2BP2, KCNJ11, MLXIPL, PPARγ, SLC30A8 and TCF7L2 to the risk of type 2 diabetes in Lebanese and Tunisian Arabs
}}

{{PMID Auto
|PMID=23462794
|Title=Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets.
|OA=1
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | Affy GenomeWide 6}}
{{on chip | Affy500k}}
{{on chip | FTDNA2}}
{{on chip | FTDNA}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}