{{Rsnum
|rsid=1476413
|Gene=MTHFR
|Chromosome=1
|position=11792243
|Orientation=minus
|GMAF=0.2176
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;G)
|geno3=(G;G)
|Gene_s=MTHFR
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;G)
| geno3=(G;G)
| CEU | 10.6 | 40.7 | 48.7
| HCB | 2.9 | 35.8 | 61.3
| JPT | 2.7 | 33.6 | 63.7
| YRI | 0.7 | 23.8 | 75.5
| ASW | 1.8 | 24.6 | 73.7
| CHB | 2.9 | 35.8 | 61.3
| CHD | 7.3 | 28.4 | 64.2
| GIH | 21.8 | 46.5 | 31.7
| LWK | 4.5 | 25.5 | 70.0
| MEX | 3.4 | 31.0 | 65.5
| MKK | 7.1 | 34.0 | 59.0
| TSI | 11.8 | 35.3 | 52.9
| HapMapRevision=28
}}{{PMID Auto
|PMID=19593234
|Title=Association analyses suggest multiple interaction effects of the methylenetetrahydrofolate reductase polymorphisms on timing of menarche and natural menopause in white women
|OA=1
}}

{{PMID Auto
|PMID=22241680
|Title=Deep sequencing study of the MTHFR gene to identify variants associated with myelomeningocele
|OA=1
}}

{{PMID Auto
|PMID=22747749
|Title=Genetic variation in Glutathione S-Transferase Omega-1, Arsenic Methyltransferase and Methylene-tetrahydrofolate Reductase, arsenic exposure and bladder cancer: a case-control study
|OA=1
}}

{{PMID Auto
|PMID=19048631
|Title=Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study.
|OA=1
}}

{{PMID Auto
|PMID=19493349
|Title=118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.
|OA=1
}}

{{PMID Auto
|PMID=20962791
|Title=Methylenetetrahydrofolate reductase gene polymorphisms and cerebral palsy in Chinese infants.
}}

{{PMID Auto
|PMID=23893618
|Title=Association of dietary and supplemental folate intake and polymorphisms in three FOCM pathway genes with colorectal cancer in a population-based case-control study
}}

{{PMID Auto
|PMID=22903727
|Title=Maternal and infant gene-folate interactions and the risk of neural tube defects.
|OA=1
}}

{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}