{{Rsnum
|rsid=1528133
|Gene=RIC3
|Chromosome=11
|position=8128206
|Orientation=plus
|GMAF=0.08907
|Assembly=GRCh38
|GenomeBuild=38.1
|dbSNPBuild=141
|geno1=(A;A)
|geno2=(A;C)
|geno3=(C;C)
|Gene_s=RIC3
}}{{ population diversity
| geno1=(A;A)
| geno2=(A;C)
| geno3=(C;C)
| CEU | 89.4 | 10.6 | 0.0
| HCB | 87.6 | 12.4 | 0.0
| JPT | 86.7 | 11.5 | 1.8
| YRI | 74.1 | 23.1 | 2.7
| ASW | 68.4 | 28.1 | 3.5
| CHB | 87.6 | 12.4 | 0.0
| CHD | 91.7 | 8.3 | 0.0
| GIH | 76.2 | 21.8 | 2.0
| LWK | 70.9 | 26.4 | 2.7
| MEX | 79.3 | 20.7 | 0.0
| MKK | 81.4 | 17.9 | 0.6
| TSI | 85.3 | 14.7 | 0.0
| HapMapRevision=28
}}[[rs1528133]], a SNP in the [[TUB]] gene, was found in a study of 492 unrelated [[type-2 diabetes]] patients to have a significant effect on body mass index and thus [[obesity]] (1.54 kg/m(2), p= 0.006). When two populations were combined, totaling ~1200 patients, the risk allele ([[rs1528133]](C) averaged an increase of 0.54 kg/m2 (CI: â€“0.19-1.26). Two additional [[TUB]] SNPs, [[rs2272382]], and [[rs2272383]], mapping to the 3' end of the gene showed similar associations and were in linkage disequilibrium with [[rs1528133]].{{PMID|16443771}}

A follow-up study of 1,680 middle-aged Dutch women found that this allele, [[rs1528133]](C), was significantly associated with increased weight (+1.88 kg, p=0.022) and body mass index (+0.56 units, p= 0.05). [[rs1528133]](C) carriers were also associated with an increased glycemic load of 1.85 units compared with non-carriers.{{PMID|18183286|OA=1
}}

{{PMID|17955208}} TUB is a candidate gene for late-onset obesity in women.

{{PMID Auto
|PMID=23153976
|Title=Relationship of RIC-3 gene rs1528133 polymorphism with varying degrees of body weight and eating behavior
}}

{{on chip | 23andMe v1}}
{{on chip | 23andMe v2}}
{{on chip | 23andMe v3}}
{{on chip | 23andMe v4}}
{{on chip | FTDNA2}}
{{on chip | HumanOmni1Quad}}
{{on chip | Illumina Human 1M}}